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Peptide record

TPDB11309

Antibacterial Anticancer Antifungal Antiparasitic standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11309
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Physicochemical Analysis
C152H239N47O44S6
AHMW
C
3621.22
8.31
5
2
8
+3
3.01
-0.326
47.10
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3355
92.65
14
Residue Composition
number
0
A
4
R
1
N
1
D
6
C
1
E
2
Q
3
G
0
H
1
I
2
L
1
K
0
M
2
F
1
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 6 E: 1 Q: 2 G: 3 H: 0 I: 1 L: 2 K: 1 M: 0 F: 2 P: 1 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
31
C152H239N47O44S6
3621.22
8.31
+3
3.01
-0.326
Evidence Records 18 records
Evidence 1 Activity

Activity

IC50
Antibacterial
6.1 µg/mL

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (I
Evidence 2 Activity

Activity

IC50
Antibacterial
12.0 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC
Evidence 3 Activity

Activity

IC50
Antibacterial
30.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

nhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aerugino
Evidence 4 Activity

Activity

IC50
Antibacterial
20.2 µg/mL

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP

Other

50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you
Evidence 5 Activity

Activity

IC50
Antibacterial
25.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted str
Evidence 6 Activity

Activity

IC50
Antibacterial
38.0 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

eld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted structure. Updated 7/2021 11/2024
Evidence 7 Activity

Activity

IC50
Antifungal
6.1 µg/mL

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (I
Evidence 8 Activity

Activity

IC50
Antifungal
12.0 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC
Evidence 9 Activity

Activity

IC50
Antifungal
30.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aerugino
Evidence 10 Activity

Activity

IC50
Antifungal
20.2 µg/mL

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you
Evidence 11 Activity

Activity

IC50
Antifungal
25.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted str
Evidence 12 Activity

Activity

IC50
Antifungal
38.0 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

eld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted structure. Updated 7/2021 11/2024
Evidence 13 Activity

Activity

IC50
Antiparasitic
6.1 µg/mL

Target

Streptococcus pyogenes

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (I
Evidence 14 Activity

Activity

IC50
Antiparasitic
12.0 µg/mL

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

Active against S. aureus (50% inhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC
Evidence 15 Activity

Activity

IC50
Antiparasitic
30.4 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

nhibition, IC50 18.2 ug/ml), S. pyogenes (IC50 6.1 ug/ml), E. faecalis (IC50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aerugino
Evidence 16 Activity

Activity

IC50
Antiparasitic
20.2 µg/mL

Target

Klebsiella oxytoca

Source & Reference

DRAMP

Other

50 12.0 ug/ml), E. coli (IC50 30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you
Evidence 17 Activity

Activity

IC50
Antiparasitic
25.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

30.4 ug/ml), Salmonella serotype krefeld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted str
Evidence 18 Activity

Activity

IC50
Antiparasitic
38.0 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

eld (IC50 24.3 ug/ml), K. oxytoca (IC50 20.2 ug/ml), P. aeruginosa (IC50 25.8 ug/ml), and C. albicans (IC50 38.0 ug/ml). UniProt P81466 : you can view AlphaFold predicted structure. Updated 7/2021 11/2024