Back to search

Peptide record

TPDB11308

Cecropin P1 Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11308
Cecropin P1
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Physicochemical Analysis
C147H253N45O43
DCHMFYV
K
3338.90
11.08
7
2
11
+5
7.86
-0.558
88.39
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
164.72
7
Residue Composition
number
4
A
2
R
1
N
0
D
0
C
2
E
1
Q
3
G
0
H
4
I
2
L
5
K
0
M
0
F
1
P
4
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 3 H: 0 I: 4 L: 2 K: 5 M: 0 F: 0 P: 1 S: 4 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
31
C147H253N45O43
3338.90
11.08
+5
7.86
-0.558
Free
L
Linear
Free
Antibacterial
Small Intestine of Pig
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

L. anguillarum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Als
Evidence 2 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

C. glutamicum

Source & Reference

dbAMP DRAMP

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. m
Evidence 5 Activity

Activity

MIC
Antibacterial
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP DRAMP

Other

Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. col
Evidence 6 Activity

Activity

MIC
Antibacterial
3-9.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. enteri
Evidence 7 Activity

Activity

MIC
Antibacterial
0.3-0.5 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP

Other

var typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.3-0.5 ug/ml) ( Lee IH et al., 1997 ). Also Active against colistin-susceptible A. baumannii (MIC 1.6 u
Evidence 8 Activity

Activity

IC50
IC50=93 µM
Anticancer
93 µM

Target

Leukemia Cancer
K-562
Blood

Assay & Model

MTT assay
96-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1994

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 9 Activity

Activity

IC50
IC50=>100 µM
Anticancer
>100 µM

Target

Breast Cancer
BTS-30
Breast

Assay & Model

MTT assay
96-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1994
Evidence 10 Activity

Activity

IC50
IC50=>100 µM
Anticancer
>100 µM

Target

Colon Cancer
HRT-18
Colon

Assay & Model

MTT assay
96-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1994
Evidence 11 Activity

Activity

IC50
IC50=>100 µM
Anticancer
>100 µM

Target

Colon Cancer
DLD-1
Colon

Assay & Model

MTT assay
96-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1994
Evidence 12 Activity

Activity

MIC
Antifungal
1.2 µM

Target

L. anguillarum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Als
Evidence 13 Activity

Activity

MIC
Antifungal
1.2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram
Evidence 14 Activity

Activity

MIC
Antifungal
1.6 µM

Target

C. glutamicum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/
Evidence 15 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. m
Evidence 16 Activity

Activity

MIC
Antifungal
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. col
Evidence 17 Activity

Activity

MIC
Antifungal
3-9.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. enteri
Evidence 18 Activity

Activity

MIC
Antifungal
0.3-0.5 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

var typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.3-0.5 ug/ml) ( Lee IH et al., 1997 ). Also Active against colistin-susceptible A. baumannii (MIC 1.6 u
Evidence 19 Activity

Activity

MIC
Antiparasitic
1.2 µM

Target

L. anguillarum

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Als
Evidence 20 Activity

Activity

MIC
Antiparasitic
1.2 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram
Evidence 21 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

C. glutamicum

Source & Reference

DRAMP

Other

Active against Gram- L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/
Evidence 22 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

L. anguillarum (MIC 1.2 uM), E. coli (MIC 1.2 uM), Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. m
Evidence 23 Activity

Activity

MIC
Antiparasitic
22.2 µg/mL

Target

Staphylococcus aureus 930918-3

Source & Reference

DRAMP

Other

Gram+ C. glutamicum (MIC 1.6 uM), and S. aureus (MIC 12.5 uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. col
Evidence 24 Activity

Activity

MIC
Antiparasitic
3-9.4 µg/mL

Target

L. monocytogenes EGD

Source & Reference

DRAMP

Other

uM). Also: Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. enteri
Evidence 25 Activity

Activity

MIC
Antiparasitic
0.3-0.5 µg/mL

Target

Pseudomonas aeruginosa MR3007

Source & Reference

DRAMP

Other

var typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.3-0.5 ug/ml) ( Lee IH et al., 1997 ). Also Active against colistin-susceptible A. baumannii (MIC 1.6 u
Evidence 26 Activity

Activity

0% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000
Evidence 27 Activity

Activity

0% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 256 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria. | PLoS One | 2015
Evidence 28 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. | Chem Biol Drug Des | 2018
Evidence 29 Activity

Activity

<10% Killing
Toxicity
128 µM
Cytotoxic
<10% Killing | 128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1. | Chem Biol Drug Des | 2018
Evidence 30 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 31 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29266746] MHC5>128 µM against human red blood cells | Cytotoxicity: [Ref.29266746] The cell viability of IPEC-J2 cells induced by CP-1 is 87.9%, 100.4%, 93.5%, 88.5%, 91.8%, 84.2% and 86.3% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 µM. The cell viability of IPEC-J2 cells induced by the control Melittin is

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2018 May 91(5):1017-1029. doi: 10.1111/cbdd.13165.