Back to search

Peptide record

TPDB11307

Palustrin - Ca Antibacterial Anticancer Antifungal Toxicity standard

31 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11307

Peptide_Name

Palustrin - Ca

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 dbACP iACP-DRLF Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Sequence

GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP

FASTA

>TPDB11307|Antibacterial;Anticancer;Antifungal;Toxicity|length=31
GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP

Formula C150H248N38O41S2

Absent Amino Acids RQHMSWY

Common Amino Acids K

Mass 3303.97

PI 9.02

Basic Residues 5

Acidic Residues 3

Hydrophobic Residues 12

Net Charge +2

Boman Index 5.17

Hydrophobicity 0.148

Aliphatic Index 103.87

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.78

Polar Residues 5

number

Amino Acid Distribution

A: 2 R: 0 N: 2 D: 2 C: 2 E: 1 Q: 0 G: 4 H: 0 I: 3 L: 4 K: 5 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C150H248N38O41S2

Mass

3303.97

9.02

Net Charge

Boman Index

5.17

Hydrophobicity

0.148

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Host Defence Peptide

Origin

Lithobates catesbeianus

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism L. monocytogenes ATCC 54004

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against L. monocytogenes ATCC 54004 (MIC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.8 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against L. monocytogenes ATCC 54004 (MIC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa A

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31.25 µg/mL

Target

Target Organism S. suis 2 CVCC 606

Source & Reference

Database Source dbAMP

Other

Evidence Text

against L. monocytogenes ATCC 54004 (MIC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa ATCC 227853 or ATCC 227853 (MIC 30-60 u

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis ADB403

Source & Reference

Database Source dbAMP

Other

Evidence Text

IC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa ATCC 227853 or ATCC 227853 (MIC 30-60 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30-60 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 227853 or ATCC 227853

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa ATCC 227853 or ATCC 227853 (MIC 30-60 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.951 µg/ml

Detail Source Activity Anticancer

Activity Measurement 0.951 µg/mL

Target

Cancer Type Gastric Cancer

Cell Line SGC-7901

Tissue Affected Stomach

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism L. monocytogenes ATCC 54004

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against L. monocytogenes ATCC 54004 (MIC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.8 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against L. monocytogenes ATCC 54004 (MIC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa A

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31.25 µg/mL

Target

Target Organism S. suis 2 CVCC 606

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis ADB403

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

IC 30 ug/ml), S. aureus ATCC 25923 (MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa ATCC 227853 or ATCC 227853 (MIC 30-60 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30-60 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 227853 or ATCC 227853

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 7.8 ug/ml), S. suis 2 CVCC 606 (MIC 31.25 ug/ml), B. subtilis ADB403 (MIC 30 ug/ml), P. aeruginosa ATCC 227853 or ATCC 227853 (MIC 30-60 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 250 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 250 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effects of Two Novel Peptides from Skin of Lithobates Catesbeianus on Tumor Cell Morphology and Proliferation | Molecular Cloning - Selected Applications in Medicine and Biology | 2011