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Peptide record

TPDB11302

Antibacterial Antifungal Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB11302
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 31-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SLWENFKNAGKQFILNILDKIRCRVAGGCRT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C157H256N48O42S2
HMPY
RNGILK
3552.18
10.32
6
2
12
+4
1.86
-0.210
91.29
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5625
1.58
8
Residue Composition
number
2
A
3
R
3
N
1
D
2
C
1
E
1
Q
3
G
0
H
3
I
3
L
3
K
0
M
2
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 3 D: 1 C: 2 E: 1 Q: 1 G: 3 H: 0 I: 3 L: 3 K: 3 M: 0 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
31 reviewed residue count
C157H256N48O42S2 sequence-only estimate (linear, free termini)
3552.18 sequence-only estimate (linear, free termini)
10.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.86 sequence-only estimate (linear, free termini)
-0.210 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC2592 (MIC 1.7 uM), B. licheniformis X39 (IS) (MIC 14 uM), and P. faecalis X29 (IS) (MIC 1.7 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
1.7 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC2592 (MIC 1.7 uM), B. licheniformis X39 (IS) (MIC 14 uM), and P. faecalis X29 (IS) (MIC 1.7 uM).
Evidence 3 Activity

Activity

Hemolysis
[Ref.22426384] It has hemolytic activities (LD50=220µM) against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochimie. 2012 Jun 94(6):1317-1326.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
220 µM
Hemolytic Cytotoxic
50% Hemolysis | 220 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii. | Biochimie | 2012
Evidence 5 Activity

Activity

LD50
Toxicity
220 µM
Hemolytic
Hemolytic_activity: [Ref.22426384] It has hemolytic activities (LD50=220µM) against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Jun 94(6):1317-1326.
Evidence 6 Hemolysis

Activity

[Ref.22426384] It has hemolytic activities (LD50=220µM) against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochimie. 2012 Jun 94(6):1317-1326.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.