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Peptide record

TPDB11301

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB11301
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KPWRFRRAIRRVRWRKVAPYIPFVVKTVGKK
Physicochemical Analysis
C185H301N59O34
NDCEQHLMS
R
3895.80
12.81
12
0
14
+12
4.61
-0.671
78.39
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
12490
320.60
2
Residue Composition
number
2
A
7
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
0
L
5
K
0
M
2
F
3
P
0
S
1
T
2
W
1
Y
5
V
Amino Acid Distribution
A: 2 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 5 M: 0 F: 2 P: 3 S: 0 T: 1 W: 2 Y: 1 V: 5
Chemical Descriptors
31
C185H301N59O34
3895.80
12.81
+12
4.61
-0.671
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
The recombinant peptide showed activity against E. coli DH5alpha or WT E4 or E9 (MBC 0.2-0.4 uM), B. megaterium ATCC 14581 (MBC 0.1 uM), and S. aureus ATCC 12600 or MRSA ATCC 43300 or ATCC 33393 or WT 344 355 or 358 (MBC 0.4-0.8 uM). In particular, synthetic version of the peptide with C-terminal amidation inhibits gram-positive vancomycin-resistant E. faecalis ATCC 51299 (MBC 1.6 uM) (anti-VRE) and 4 strains E. faecium strains 354, 356, G70 and G71 (MBC 0.4-0.8 uM). It was also active against gram-negative ESBL strain K. pneumoniae (MBC 0.4-0.8 uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
The recombinant peptide showed activity against E. coli DH5alpha or WT E4 or E9 (MBC 0.2-0.4 uM), B. megaterium ATCC 14581 (MBC 0.1 uM), and S. aureus ATCC 12600 or MRSA ATCC 43300 or ATCC 33393 or WT 344 355 or 358 (MBC 0.4-0.8 uM). In particular, synthetic version of the peptide with C-terminal amidation inhibits gram-positive vancomycin-resistant E. faecalis ATCC 51299 (MBC 1.6 uM) (anti-VRE) and 4 strains E. faecium strains 354, 356, G70 and G71 (MBC 0.4-0.8 uM). It was also active against gram-negative ESBL strain K. pneumoniae (MBC 0.4-0.8 uM).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

NA

Other

The recombinant peptide showed activity against E. coli DH5alpha or WT E4 or E9 (MBC 0.2-0.4 uM), B. megaterium ATCC 14581 (MBC 0.1 uM), and S. aureus ATCC 12600 or MRSA ATCC 43300 or ATCC 33393 or WT 344 355 or 358 (MBC 0.4-0.8 uM). In particular, synthetic version of the peptide with C-terminal amidation inhibits gram-positive vancomycin-resistant E. faecalis ATCC 51299 (MBC 1.6 uM) (anti-VRE) and 4 strains E. faecium strains 354, 356, G70 and G71 (MBC 0.4-0.8 uM). It was also active against gram-negative ESBL strain K. pneumoniae (MBC 0.4-0.8 uM).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

NA

Other

The recombinant peptide showed activity against E. coli DH5alpha or WT E4 or E9 (MBC 0.2-0.4 uM), B. megaterium ATCC 14581 (MBC 0.1 uM), and S. aureus ATCC 12600 or MRSA ATCC 43300 or ATCC 33393 or WT 344 355 or 358 (MBC 0.4-0.8 uM). In particular, synthetic version of the peptide with C-terminal amidation inhibits gram-positive vancomycin-resistant E. faecalis ATCC 51299 (MBC 1.6 uM) (anti-VRE) and 4 strains E. faecium strains 354, 356, G70 and G71 (MBC 0.4-0.8 uM). It was also active against gram-negative ESBL strain K. pneumoniae (MBC 0.4-0.8 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
61.02 µM
Cytotoxic
IC50 | 61.02 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells. | Drug Des Devel Ther | 2018
Evidence 6 Activity

Activity

IC50
Toxicity
50.58 µM
Cytotoxic
IC50 | 50.58 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells. | Drug Des Devel Ther | 2018
Evidence 7 Activity

Activity

IC50
Toxicity
275.4 µM
Cytotoxic
IC50 | 275.4 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells. | Drug Des Devel Ther | 2018
Evidence 8 Activity

Activity

15% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells. | Drug Des Devel Ther | 2018
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources. | Antimicrob Agents Chemother | 2009