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Peptide record

TPDB11296

F3 peptides F3 Antibacterial Anticancer Antifungal Tumor-homing Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB11296
F3 peptides F3
Antibacterial Anticancer Antifungal Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP StackTHP StackTHPred TumorHoPe2.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK
Physicochemical Analysis
C152H263N49O41
NCGHIMFTWYV
KP
3433.06
11.26
11
3
6
+8
18.65
-1.945
28.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
5
A
3
R
0
N
1
D
0
C
2
E
1
Q
0
G
0
H
0
I
1
L
8
K
0
M
0
F
8
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 3 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 8 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
31
C152H263N49O41
3433.06
11.26
+8
18.65
-1.945
Evidence Records 8 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Nucleus of tumor cells
Homing
Peritoneal carcinomatosis
Nucleoin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Treatment of Peritoneal Carcinomatosis by Targeted Delivery of the Radio-Labeled Tumor Homing Peptide 213Bi-DTPA-[F3]2 into the Nucleus of Tumor Cells
2009
Drecoll E et al. PLoS One. 2009 May 27 4(5):e5715.
EP1783140A3,US 7,544,767B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
EMT6, MIAPACA, CMT93, OVCAR3, MDA-MB-435 cell line
Mice bearing intra-peritoneal MDA-MB-435 xenograft tumors
Recombinant phage-displayed
Bi-DTPA-[F3]2
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Breast cancer
Nucleolin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Silk-based nanocomplexes with tumor-homing peptides for tumor-specific gene delivery.
2011
Numata K et al. Macromol Biosci 2012 Jan 12(1):75-82.
US 7,544,767 B2

Other

MDA-MB-435 melanoma cell line, MDA-MB-231 human breast tumor cell line
Synthetic
Silk-based ionic pDNA complexes
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel
Homing
Breast tumor
Nucleolin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Spider silk-based gene carriers for tumor cell-specific delivery.
2011
Numata K et al .Bioconjug Chem 2011 Aug 17 22(8):1605-10.
US 7,544,767 B2

Other

MDA-MB-435 melanoma cell line, MDA-MB-231
Mice bearing MDA-MB-231
Synthetic
pDNA complexes of silk proteins containing poly(L-lysine)
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2017
Ham S et al. Acta Pharmacol Sin. 2017 Jun 38(6):897-906.

Other

U87 MG, HeLa, LnCaP, 9L, 293 HEK, SVGp12
Male athumic nude mice bearing U87 MG sc xenograft
Gelonin
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell
Homing
Colorectal cancer, Umbilical vein endothelial

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Homing and Penetrating Peptide-Functionalized Photosensitizer-Conjugated PEG-PLA Nanoparticles for Chemo-Photodynamic Combination Therapy of Drug-Resistant Cancer
2016
Feng X et al. ACS Appl Mater Interfaces. 2016 Jul 20 8(28):17817-32.

Other

HUVEC cells and HCT-15 cells were applied to study the cellular selectivity
Male BALB/c nude mice, injected with HCT-15 cells to establish the colorectal tumor model
Synthetic
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2015
Hu J et al. Chem Commun (Camb). 2015 Jul 21 51(57):11405-8.

Other

elastin-like polypeptide
Additional Detail Fields 4 fields
Bi-DTPA-[F3]2 Silk-based ionic pDNA complexes pDNA complexes of silk proteins containing poly(L-lysine) Nanoworms(NWs), polyethylene glycol necrosis-inducing peptide, Fluorescein (FAM) Gelonin elastin-like polypeptide
EMT6, MIAPACA, CMT93, OVCAR3, MDA-MB-435 cell line MDA-MB-435 melanoma cell line, MDA-MB-231 human breast tumor cell line MDA-MB-435 melanoma cell line, MDA-MB-231 Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line U87 MG, HeLa, LnCaP, 9L, 293 HEK, SVGp12 HUVEC cells and HCT-15 cells were applied to study the cellular selectivity
Mice bearing intra-peritoneal MDA-MB-435 xenograft tumors Mice bearing MDA-MB-231 Athymic nude mice, ApoE null mice 6-week-old BalB/C mice Male athumic nude mice bearing U87 MG sc xenograft Male BALB/c nude mice, injected with HCT-15 cells to establish the colorectal tumor model
T7 phage / cyclic Cx7C and linear X7 peptide library