TPDB11294

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.6-37 ug/mL

Target

Target Organism Staphylococcus aureus ATCC25923 or MRSA

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids

Source & Reference

Database Source dbAMP

Other

Evidence Text

t Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.17 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP

Other

Evidence Text

MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli AT

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 ug/mL

Target

Target Organism Enterococcus faecalis IS 981

Source & Reference

Database Source dbAMP

Other

Evidence Text

epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoc

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 ug/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP

Other

Evidence Text

steroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 73

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP

Other

Evidence Text

75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism S. paratyphi IS 738

Source & Reference

Database Source dbAMP

Other

Evidence Text

9 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.17 µg/mL

Target

Target Organism D. bacillus

Source & Reference

Database Source dbAMP

Other

Evidence Text

5922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 278

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP

Other

Evidence Text

oca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fun

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.69 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP

Other

Evidence Text

IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-37.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

illus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 ug/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It also shows antibiofilm activity and anti-infla

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism C. glabrata

Source & Reference

Database Source dbAMP

Other

Evidence Text

ginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It also shows antibiofilm activity and anti-inflammatory activity. This peptide also sho

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.62 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP

Other

Evidence Text

V. anguillarum, V. brasiliensis, V. cholerae, V. fluvialis, V. harveyi (MIC all 2.47 uM), V. parahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM),

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.47 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP

Other

Evidence Text

cholerae, V. fluvialis, V. harveyi (MIC all 2.47 uM), V. parahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.ve

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.23 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP

Other

Evidence Text

arahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.29 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP

Other

Evidence Text

, V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang et al., 2022 ).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.93 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP

Other

Evidence Text

uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang et al., 2022 ).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.6-37 ug/mL

Target

Target Organism Staphylococcus aureus ATCC25923 or MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

t Gram+ S. aureus ATCC25923 or MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.17 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MRSA (MIC 4.6-37 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli AT

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 ug/mL

Target

Target Organism Enterococcus faecalis IS 981

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoc

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 ug/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

steroids (MIC 9.38 ug/ml), B. cereus (MIC 1.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 73

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.17 ug/ml), E. faecalis IS 981 (MIC 75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

75 ug/mL), E. faecium IS 1299 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism S. paratyphi IS 738

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

9 (MIC 9.38 ug/mL), Gram- E. coli ATCC25922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.17 µg/mL

Target

Target Organism D. bacillus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

5922 (MIC 9.38 ug/ml), K. oxytoca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 278

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

oca (MIC 75 ug/ml) , S. paratyphi IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fun

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.69 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

IS 738 (MIC 18.75 ug/ml), D. bacillus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-37.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

illus (MIC 1.17 ug/ml), K. pneumoniae (MIC 18.75 ug/ml), S. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 ug/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

. maltophilia (MIC 4.69 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It also shows antibiofilm activity and anti-infla

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism C. glabrata

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ginosa ATCC 27853 (MIC 9.38-37.5 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). It also shows antibiofilm activity and anti-inflammatory activity. This peptide also sho

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.62 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

V. anguillarum, V. brasiliensis, V. cholerae, V. fluvialis, V. harveyi (MIC all 2.47 uM), V. parahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM),

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.47 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

cholerae, V. fluvialis, V. harveyi (MIC all 2.47 uM), V. parahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.ve

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.23 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

arahaemolyticus (MIC 0.62 uM), V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.29 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

, V. splendidus (MIC 2.47 uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang et al., 2022 ).

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.93 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

uM), V. vulnificus. (MIC 4.93 uM), A. hydrophila (MIC 1.23 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 4.93 uM), and N. asteroides (MIC 4.93) ( Ouyang et al., 2022 ).

Evidence 41 Activity

Activity

Activity Endpoint 6.63% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

6.63% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 42 Activity

Activity

Activity Endpoint 4.46% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

4.46% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Target Cell Human hepatocyte cells HL-7702 (L02)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 43 Activity

Activity

Activity Endpoint 6.46% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

6.46% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Target Cell Murine peritoneal macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 44 Activity

Activity

Activity Endpoint 10.97% Degranulation

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

10.97% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018