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Peptide record

TPDB11287

dermaseptin-PD-1 Antibacterial Anticancer Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB11287
dermaseptin-PD-1
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GMWSKIKETAMAAAKEAAKAAGKTISDMIKQ
Physicochemical Analysis
C141H241N39O43S3
RNCHLFPYV
A
3266.88
10.27
6
3
15
+3
7.52
-0.274
63.55
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
168.36
5
Residue Composition
number
8
A
0
R
0
N
1
D
0
C
2
E
1
Q
2
G
0
H
3
I
0
L
6
K
3
M
0
F
0
P
2
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 3 L: 0 K: 6 M: 3 F: 0 P: 0 S: 2 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
31
C141H241N39O43S3
3266.88
10.27
+3
7.52
-0.274
Free
L
Linear
Free
Antimicrobial
phyllomedusine leaf frogs,Pachymedusa dacnicolor
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
19.6 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are hig
Evidence 2 Activity

Activity

MIC
Antibacterial
39.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are higher.
Evidence 3 Activity

Activity

MIC
Antibacterial
19.6 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are higher.
Evidence 4 Activity

Activity

IC50
IC50 = 15.08 µM
Anticancer
15.08 µM

Target

Brain Tumor
U251-MG
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2016

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

MIC
Antifungal
19.6 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are hig
Evidence 6 Activity

Activity

MIC
Antifungal
39.2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are higher.
Evidence 7 Activity

Activity

MIC
Antifungal
19.6 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 19.6 uM), S. aureus (MIC 39.2 uM), C. albicans (39.2 uM), P. aeruginosa (MIC 19.6 uM). MBC are higher.
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. | Toxins (Basel) | 2016
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2016 May 12 8(5):144.