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Peptide record

TPDB11282

Antibacterial Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB11282
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KRFQNFFRELEKKFREFFRVYRITIGATIRF
Physicochemical Analysis
C192H292N54O43
DCHMPSW
F
4044.77
11.79
9
3
14
+6
4.74
-0.529
62.90
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
36.84
5
Residue Composition
number
1
A
6
R
1
N
0
D
0
C
3
E
1
Q
1
G
0
H
3
I
1
L
3
K
0
M
7
F
0
P
0
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 1 D: 0 C: 0 E: 3 Q: 1 G: 1 H: 0 I: 3 L: 1 K: 3 M: 0 F: 7 P: 0 S: 0 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
31
C192H292N54O43
4044.77
11.79
+6
4.74
-0.529
Evidence Records 4 records
Evidence 1 Activity

Activity

9.14% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
9.14% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2012
Evidence 2 Activity

Activity

8.42% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
8.42% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2012
Evidence 3 Activity

Activity

4.65% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
4.65% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2012
Evidence 4 Activity

Activity

11.10% Degranulation
Toxicity
100 µg/mL
Cytotoxic
11.10% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2012