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Peptide record

TPDB11271

Antibacterial Antifungal Hemolysis Toxicity standard

31 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11271

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWNTIKEAGKKFAINVLDKIRCGIAGGCKT

FASTA

>TPDB11271|Antibacterial;Antifungal;Hemolysis;Toxicity|length=31
GLWNTIKEAGKKFAINVLDKIRCGIAGGCKT

Formula C147H246N42O40S2

Absent Amino Acids QHMPSY

Common Amino Acids GK

Mass 3305.95

PI 10.06

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 12

Net Charge +4

Boman Index 3.92

Hydrophobicity 0.023

Aliphatic Index 94.52

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5625

Absorbance 280nm 170.15

Polar Residues 6

number

Amino Acid Distribution

A: 3 R: 1 N: 2 D: 1 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 4 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 1

Length

Formula

C147H246N42O40S2

Mass

3305.95

10.06

Net Charge

Boman Index

3.92

Hydrophobicity

0.023

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

ve bacteria: R. rhodochrous X15 (IS) (MIC 2.3 uM), B. licheniformis X39 (IS) (MIC 19 uM), E. faecalis 981 (MIC 75 uM), S. carnosus KHS (IS)(MIC 19 uM), S.aureus ATCC 25923(MIC 150 uM), E.coli ATCC 25922 (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ormis X39 (IS) (MIC 19 uM), E. faecalis 981 (MIC 75 uM), S. carnosus KHS (IS)(MIC 19 uM), S.aureus ATCC 25923(MIC 150 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P.aeruginosa 1105

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 150 µM

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ecalis 981 (MIC 75 uM), S. carnosus KHS (IS)(MIC 19 uM), S.aureus ATCC 25923(MIC 150 uM), E.coli ATCC 25922 (MIC 150 uM), P.aeruginosa CGMCC 1.50 (MIC >150 uM), P.aeruginosa 11053 (IS)(MIC >150 uM), K.pneumonia

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

724 (IS)(MIC 150 uM), P. faecalis X29 (IS)(MIC 4.5 uM), S. rubidaea X01 (IS)(MIC 4.6 uM), C.albicans ATCC 10231 (MIC >150 uM), Slime mold 090223 (IS) (MIC 4.5 uM). IS: Isolated strain.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µM

Target

Target Organism Enterococcus faecalis 981

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 150 µM

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.albicans ATCC 10231

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

724 (IS)(MIC 150 uM), P. faecalis X29 (IS)(MIC 4.5 uM), S. rubidaea X01 (IS)(MIC 4.6 uM), C.albicans ATCC 10231 (MIC >150 uM), Slime mold 090223 (IS) (MIC 4.5 uM). IS: Isolated strain.

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 75 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis | Peptides | 2012

Evidence 10 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.