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Peptide record

TPDB11268

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11268
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SLWETIKNAGKGFILNILDKIRCKVAGGCKT
Physicochemical Analysis
C151H254N42O41S2
QHMPY
K
3378.05
10.06
6
2
12
+4
3.65
0.074
103.87
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5625
166.52
7
Residue Composition
number
2
A
1
R
2
N
1
D
2
C
1
E
0
Q
4
G
0
H
4
I
3
L
5
K
0
M
1
F
0
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 2 E: 1 Q: 0 G: 4 H: 0 I: 4 L: 3 K: 5 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
31
C151H254N42O41S2
3378.05
10.06
+4
3.65
0.074
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
11.25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002
Evidence 2 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/m
Evidence 3 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

tive against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/ml. Updated 7/2020
Evidence 4 Activity

Activity

MIC
Antifungal
11.25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002
Evidence 5 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/m
Evidence 6 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tive against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/ml. Updated 7/2020
Evidence 7 Activity

Activity

MIC
Antiparasitic
11.25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002
Evidence 8 Activity

Activity

MIC
Antiparasitic
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/m
Evidence 9 Activity

Activity

MIC
Antiparasitic
9.38 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

tive against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/ml. Updated 7/2020
Evidence 10 Activity

Activity

MIC
Antiviral
11.25 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002
Evidence 11 Activity

Activity

MIC
Antiviral
9.38 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/m
Evidence 12 Activity

Activity

MIC
Antiviral
9.38 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

tive against S. aureus ATCC25923 (MIC 11.25 ug/ml), S. aureus ATCC43300 (MIC 9.38 ug/ml), B. subtilis (MIC 9.38 ug/ml), C. albicans ATCC2002 (15 ug/ml). 85% hemolysis at 100 ug/ml. Updated 7/2020
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
3.26 %
[Ref:19778602]85.52 ± 3.26% hemolytic activity at 50 µg/ml against rabbit red cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Genomics. 2010 Jan 95(1):66-71.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

86% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
86% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 15 Activity

Activity

(29.78±4.24)% Degranulation
Toxicity
50 µg/mL
Cytotoxic
(29.78±4.24)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 16 Activity

Activity

85.3% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
85.3% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 17 Activity

Activity

67.1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
67.1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 18 Activity

Activity

40.1% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
40.1% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 19 Activity

Activity

23.0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
23.0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 20 Activity

Activity

11.9% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
11.9% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 21 Activity

Activity

0% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 22 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:19778602]85.52 ± 3.26% hemolytic activity at 50 µg/ml against rabbit red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Genomics. 2010 Jan 95(1):66-71.
Evidence 23 Hemolysis

Activity

3.26 %
% Hemolysis
[Ref:19778602]85.52 ± 3.26% hemolytic activity at 50 µg/ml against rabbit red cells
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Genomics. 2010 Jan 95(1):66-71.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.