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Peptide record

TPDB11254

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11254
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILQKAVLDCLKAAGSSLSKAAITAIYNKIT
Physicochemical Analysis
C139H242N36O41S1
REHMFPW
A
3105.73
9.97
4
1
16
+3
1.26
0.637
133.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
47.98
9
Residue Composition
number
6
A
0
R
1
N
1
D
1
C
0
E
1
Q
1
G
0
H
4
I
4
L
4
K
0
M
0
F
0
P
3
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 1 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 4 L: 4 K: 4 M: 0 F: 0 P: 0 S: 3 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
30
C139H242N36O41S1
3105.73
9.97
+3
1.26
0.637
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
On the weight basis, the monomer and dimer are equally active. radial di¡usion assays: active against Gram- E. coli, P. aeruginosa, Gram+ bacteria L. monocytogenes, S. aureus.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
On the weight basis, the monomer and dimer are equally active. radial di¡usion assays: active against Gram- E. coli, P. aeruginosa, Gram+ bacteria L. monocytogenes, S. aureus.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

On the weight basis, the monomer and dimer are equally active. radial di¡usion assays: active against Gram- E. coli, P. aeruginosa, Gram+ bacteria L. monocytogenes, S. aureus.
Evidence 4 Activity

Activity

% Hemolysis
Hemolysis
10 20 %
[Ref.11479030]10% hemolytic activity at 50 µg/ml, 20% hemolytic activity at 100 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2001 Aug 15 1527(3):141-148.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. | Biochim Biophys Acta | 2001
Evidence 6 Activity

Activity

21% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
21% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. | Biochim Biophys Acta | 2001
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11479030]10% hemolytic activity at 50 µg/ml, 20% hemolytic activity at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2001 Aug 15 1527(3):141-148.
Evidence 8 Hemolysis

Activity

10 20 %
% Hemolysis
[Ref.11479030]10% hemolytic activity at 50 µg/ml, 20% hemolytic activity at 100 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2001 Aug 15 1527(3):141-148.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.