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Peptide record

TPDB11253

Cliotide T2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11253
Cliotide T2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GEFLKCGESCVQGECYTPGCSCDWPICKKN
Physicochemical Analysis
C138H210N36O45S6
ARHM
C
3285.76
4.65
3
4
6
-1
6.44
-0.390
35.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
224.15
12
Residue Composition
number
0
A
0
R
1
N
1
D
6
C
3
E
1
Q
4
G
0
H
1
I
1
L
3
K
0
M
1
F
2
P
2
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 6 E: 3 Q: 1 G: 4 H: 0 I: 1 L: 1 K: 3 M: 0 F: 1 P: 2 S: 2 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
30
C138H210N36O45S6
3285.76
4.65
-1
6.44
-0.390
Free
L
Not Available
Free
Antibacterial
Clitoria ternatea
Evidence Records 5 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

HD50
Hemolysis
100 µM
[Ref:21596752] HD50>100 µM against human type A erythrocytes

Target

human type A erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Biol Chem. 2011 Jul 8 286(27):24275-24287.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. | J Biol Chem | 2011
Evidence 4 Activity

Activity

HD50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:21596752] HD50>100 µM against human type A erythrocytes | Cytotoxicity: [Ref.21596752] Cytotoxicity: HeLa Cells (IC50=8.0 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
Evidence 5 Hemolysis

Activity

100 µM
HD50
[Ref:21596752] HD50>100 µM against human type A erythrocytes
Hemolysis

Target

human type A erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.