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Peptide record

TPDB11247

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

30 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11247

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF

FASTA

>TPDB11247|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=30
KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF

Formula C176H290N48O35

Absent Amino Acids NDCQHMTWY

Common Amino Acids K

Mass 3638.54

PI 12.21

Basic Residues 12

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +11

Boman Index 7.74

Hydrophobicity -0.537

Aliphatic Index 71.33

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 9 M: 0 F: 5 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C176H290N48O35

Mass

3638.54

12.21

Net Charge

+11

Boman Index

7.74

Hydrophobicity

-0.537

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.3 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.2 µM

Target

Target Organism Pseudomonas aeruginosa ATCC278953

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM). The peptide and its lysine 16 variant

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

li ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM). The peptide and its lysine 16 variant also possesses anticancer effects (Tian Y et al. 2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.3 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.2 µM

Target

Target Organism Pseudomonas aeruginosa ATCC278953

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM). The peptide and its lysine 16 variant

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.3 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.2 µM

Target

Target Organism Pseudomonas aeruginosa ATCC278953

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 2.3 uM), P. aeruginosa ATCC278953 (MIC 1.2 uM), S. aureus ATCC2592, and C. albicans (MIC 4.7 uM). The peptide and its lysine 16 variant

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. | PLoS One | 2008

Evidence 11 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011

Evidence 12 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >320 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016

Evidence 13 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >320 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016

Evidence 14 Activity

Activity

Activity Endpoint 7% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 320 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

7% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.18795096]Non-hemolytic activity at 400 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

PLoS One. 2008 Sep 16 3(9):e3217.##Peptides. 2008 Oct 29(10):1685-1691.