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Peptide record

TPDB11246

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11246
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIRCPKSWKCKAFKQRVLKRLLAMLRQHAF
Physicochemical Analysis
C164H274N52O34S3
NDETY
K
3614.49
12.01
10
0
13
+9
3.09
-0.320
84.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
155.62
5
Residue Composition
number
3
A
4
R
0
N
0
D
2
C
0
E
2
Q
1
G
1
H
1
I
4
L
5
K
1
M
2
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 1 H: 1 I: 1 L: 4 K: 5 M: 1 F: 2 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
30
C164H274N52O34S3
3614.49
12.01
+9
3.09
-0.320
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Hemolysis
7 µM
[Ref.21933345] EC50=7 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
FEBS J. 2011 Nov 278(22):4382-4393.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
7 µM
Hemolytic Cytotoxic
50% Hemolysis | 7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin. | FEBS J | 2011
Evidence 3 Activity

Activity

EC50
Toxicity
7 µM
Hemolytic
Hemolytic_activity: [Ref.21933345] EC50=7 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS J. 2011 Nov 278(22):4382-4393.
Evidence 4 Hemolysis

Activity

7 µM
EC50
[Ref.21933345] EC50=7 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
FEBS J. 2011 Nov 278(22):4382-4393.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.