Back to search

Peptide record

TPDB11240

HNP-3 Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11240
HNP-3
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP DRAVP 2.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DCYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
C151H228N44O40S6
NHKMSV
C
3492.10
8.01
4
2
12
+2
-1.55
0.123
62.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
10345
296.24
11
Residue Composition
number
3
A
4
R
0
N
1
D
6
C
1
E
1
Q
3
G
0
H
3
I
1
L
0
K
0
M
1
F
1
P
0
S
1
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 0 I: 3 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 3 V: 0
Chemical Descriptors
30
C151H228N44O40S6
3492.10
8.01
+2
-1.55
0.123
Free
L
Not Available
Free
Anticancer
Homo sapiens
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-3 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types) HNPs 1-3 and HD-5 have been reported to be present in the female genital tract at levels that overlap those that inhibit HPVs in vitro ( Buck et al., 2006 ). HNP-3 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins ( Xu et al., 2021 ). anti-toxin: HNP3 can partially protect human neutrophils against Panton-Valentine leukocidin of S. aureus by reducing PVL pore formation ( Cardot-Martin E et al. 2015 ).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Fibrosarcoma
Not Available
Fibrous connective tissue

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1985

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-3 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types) HNPs 1-3 and HD-5 have been reported to be present in the female genital tract at levels that overlap those that inhibit HPVs in vitro ( Buck et al., 2006 ). HNP-3 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins ( Xu et al., 2021 ). anti-toxin: HNP3 can partially protect human neutrophils against Panton-Valentine leukocidin of S. aureus by reducing PVL pore formation ( Cardot-Martin E et al. 2015 ).
Evidence 4 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-3 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types) HNPs 1-3 and HD-5 have been reported to be present in the female genital tract at levels that overlap those that inhibit HPVs in vitro ( Buck et al., 2006 ). HNP-3 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins ( Xu et al., 2021 ). anti-toxin: HNP3 can partially protect human neutrophils against Panton-Valentine leukocidin of S. aureus by reducing PVL pore formation ( Cardot-Martin E et al. 2015 ).
Evidence 5 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-3 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types) HNPs 1-3 and HD-5 have been reported to be present in the female genital tract at levels that overlap those that inhibit HPVs in vitro ( Buck et al., 2006 ). HNP-3 is active against pseudotyped viruses expressing SARS-CoV-2 spike proteins ( Xu et al., 2021 ). anti-toxin: HNP3 can partially protect human neutrophils against Panton-Valentine leukocidin of S. aureus by reducing PVL pore formation ( Cardot-Martin E et al. 2015 ).