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Peptide record

TPDB11237

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11237
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GWWRRTVDKVRNAGRKVAGFASKACGALGH
Physicochemical Analysis
C143H228N50O36S1
EQIMPY
AG
3255.76
11.98
8
1
12
+6
2.87
-0.483
58.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
337.86
4
Residue Composition
number
5
A
4
R
1
N
1
D
1
C
0
E
0
Q
5
G
1
H
0
I
1
L
3
K
0
M
1
F
0
P
1
S
1
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 4 N: 1 D: 1 C: 1 E: 0 Q: 0 G: 5 H: 1 I: 0 L: 1 K: 3 M: 0 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 3
Chemical Descriptors
30
C143H228N50O36S1
3255.76
11.98
+6
2.87
-0.483
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

C. glutamicum

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
al activity as the light chain (B) was inactive (MIC > 100 uM). Active against planktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updat
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

n (B) was inactive (MIC > 100 uM). Active against planktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updated 7/2021 11/2023 5/202
Evidence 3 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

ktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updated 7/2021 11/2023 5/2024
Evidence 4 Activity

Activity

MIC
Antifungal
0.78 µM

Target

C. glutamicum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
al activity as the light chain (B) was inactive (MIC > 100 uM). Active against planktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updat
Evidence 5 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

n (B) was inactive (MIC > 100 uM). Active against planktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updated 7/2021 11/2023 5/202
Evidence 6 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ktonic C. glutamicum (MIC 0.78 uM), S. aureus (MIC 0.78 uM), E. coli #1 (MIC 0.1 uM), and P. aeruginosa (MIC 0.78 uM). Updated 7/2021 11/2023 5/2024
Evidence 7 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. | PLoS One | 2016
Evidence 8 Activity

Activity

13.5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
13.5% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 9 Activity

Activity

74.6% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
74.6% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 10 Activity

Activity

IC50
Toxicity
125 µM
Cytotoxic
IC50 | 125 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 11 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
EBioMedicine. 2020 May 55:102775.
Evidence 12 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.