Back to search

Peptide record

TPDB11226

Antibacterial Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11226
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GAFGDLLKGVAKEAGLKLLNMAQCKLSGNC
Physicochemical Analysis
C132H225N37O39S3
RHIPTWY
L
3050.64
9.05
4
2
13
+2
3.00
0.267
101.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.10
6
Residue Composition
number
4
A
0
R
2
N
1
D
2
C
1
E
1
Q
5
G
0
H
0
I
6
L
4
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 2 E: 1 Q: 1 G: 5 H: 0 I: 0 L: 6 K: 4 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
30
C132H225N37O39S3
3050.64
9.05
+2
3.00
0.267
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 100 uM), E.faecium 091299 (IS) (MIC 200 uM), E. faecalis 981 (IS) (MIC 100 uM), N. asteroides 201
Evidence 2 Activity

Activity

MIC
Antibacterial
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

(MIC 400 uM), K.Pneumoniae 08040724 (IS) (MIC 400 uM), E.cloacae CGMCC 1.57 (MIC 200 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 6.3 uM), C.glabrata 090902 (IS) (MIC >400 uM), C.albicans ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 6.3 uM), C.glabrata 090902 (IS) (MIC >400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 100 uM), E.faecium 091299 (IS) (MIC 200 uM), E. faecalis 981 (IS) (MIC 100 uM), N. asteroides 201
Evidence 5 Activity

Activity

MIC
Antifungal
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 400 uM), K.Pneumoniae 08040724 (IS) (MIC 400 uM), E.cloacae CGMCC 1.57 (MIC 200 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 6.3 uM), C.glabrata 090902 (IS) (MIC >400 uM), C.albicans ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 6.3 uM), C.glabrata 090902 (IS) (MIC >400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

12% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
12% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013