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Peptide record

TPDB11210

Antibacterial Anticancer Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11210
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KFFKKLKNSVKKRAKKFFKKPRVIGVSIPF
Physicochemical Analysis
C175H289N47O34
DCEQHMTWY
K
3595.51
12.49
12
0
12
+12
6.32
-0.517
71.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
10
K
0
M
5
F
2
P
2
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 10 M: 0 F: 5 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
30
C175H289N47O34
3595.51
12.49
+12
6.32
-0.517
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.56-12.5 µg/mL

Target

Escherichia coli ATCC 25922 or ML-35p or 6 clincal strains

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (M
Evidence 2 Activity

Activity

MIC
Antibacterial
3.1-25 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influen
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Enterobacter aerogenes

Source & Reference

dbAMP DRAMP

Other

5922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumon
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25-12.5 µg/mL

Target

Pseudomonas aeruginosa strains

Source & Reference

dbAMP DRAMP

Other

ns (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 2
Evidence 5 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

H. influenzae

Source & Reference

dbAMP DRAMP

Other

-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.
Evidence 6 Activity

Activity

MIC
Antibacterial
3.1-6.2 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 2
Evidence 7 Activity

Activity

MIC
Antibacterial
3.125-6.25 µg/mL

Target

Staphylococcus aureus ATCC 25923 or ATCC 43300 MRSA

Source & Reference

dbAMP DRAMP

Other

6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
1.56-12.5 µg/mL

Target

Escherichia coli ATCC 25922 or ML-35p or 6 clincal strains

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (M
Evidence 11 Activity

Activity

MIC
Antifungal
3.1-25 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influen
Evidence 12 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Enterobacter aerogenes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5922 or ML-35p or 6 clincal strains (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumon
Evidence 13 Activity

Activity

MIC
Antifungal
6.25-12.5 µg/mL

Target

Pseudomonas aeruginosa strains

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ns (MIC 1.56-12.5 ug/ml), E. cloacae (MIC 3.1-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 2
Evidence 14 Activity

Activity

MIC
Antifungal
3.1 µg/mL

Target

H. influenzae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-25 ug/ml), E. aerogenes (MIC 6.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.
Evidence 15 Activity

Activity

MIC
Antifungal
3.1-6.2 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.25 ug/ml), 4 P. aeruginosa strains (MIC 6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 2
Evidence 16 Activity

Activity

MIC
Antifungal
3.125-6.25 µg/mL

Target

Staphylococcus aureus ATCC 25923 or ATCC 43300 MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6.25-12.5 ug/ml), H. influenzae (MIC 3.1 ug/ml), K. pneumoniae (MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 3.1-6.2 ug/ml), Gram+ S. aureus ATCC 25923 or ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ATCC 43300 MRSA (MIC 3.125-6.25 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), and fungi C.albicans (MIC >200 ug/ml).
Evidence 19 Activity

Activity

0.13% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0.13% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of king cobra cathelicidin. | Peptides | 2010
Evidence 20 Activity

Activity

0.62% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0.62% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of king cobra cathelicidin. | Peptides | 2010
Evidence 21 Activity

Activity

0.69% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0.69% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationship of king cobra cathelicidin. | Peptides | 2010
Evidence 22 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic
Hemolytic_activity: [Ref.22491685] 3% hemolysis at 100 µg/ml , 5% hemolysis at 200 µg/ml , 6% hemolysis at 300 µg/ml , 7% hemolysis at 400 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2008 Oct 29(10):1685-91. ##Antimicrob Agents Chemother. 2012 Jun 56(6):3309-17. doi: 10.1128/AAC.06304-11.