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Peptide record

TPDB11182

Antibacterial Antifungal Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11182
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GAFGNLLKGVAKKAGLKILSIAQCKLSGTC
Physicochemical Analysis
C133H233N37O36S2
RDEHMPWY
GLK
2990.66
10.39
5
0
13
+5
0.76
0.547
114.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.18
7
Residue Composition
number
4
A
0
R
1
N
0
D
2
C
0
E
1
Q
5
G
0
H
2
I
5
L
5
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 5 H: 0 I: 2 L: 5 K: 5 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
30
C133H233N37O36S2
2990.66
10.39
+5
0.76
0.547
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 6.3 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 20
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

IC 100 uM), K. Pneumoniae 08040724 (IS) (MIC 25 uM), E. cloacae CGMCC 1.57 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (IS) (MIC 3.1 uM), C. glabrata 090902 (IS) (MIC 100 uM), C.albicans ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP

Other

922 (MIC 25 uM), P. faecalis X29 (IS) (MIC 3.1 uM), C. glabrata 090902 (IS) (MIC 100 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (IS) (MIC 6.3 uM), E. faecalis 981 (IS) (MIC 3.1 uM), N. asteroides 20
Evidence 5 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 100 uM), K. Pneumoniae 08040724 (IS) (MIC 25 uM), E. cloacae CGMCC 1.57 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 25 uM), P. faecalis X29 (IS) (MIC 3.1 uM), C. glabrata 090902 (IS) (MIC 100 uM), C.albicans ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

922 (MIC 25 uM), P. faecalis X29 (IS) (MIC 3.1 uM), C. glabrata 090902 (IS) (MIC 100 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

13% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
13% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 9 Activity

Activity

53% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
53% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.