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Peptide record

TPDB11181

Brevinin-2GU Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Cell-penetrating Peptides Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11181
Brevinin-2GU
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0 DBAASP
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GVIIDTLKGAAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
C135H238N40O40S2
QMFPWY
A
3125.74
9.71
6
2
13
+3
5.92
0.303
114.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.00
7
Residue Composition
number
5
A
1
R
1
N
1
D
2
C
1
E
0
Q
2
G
1
H
2
I
4
L
4
K
0
M
0
F
0
P
1
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
30
C135H238N40O40S2
3125.74
9.71
+3
5.92
0.303
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Candida albicans

Source & Reference

NA

Other

Active against S. aureus (MIC 64 uM), E. coli (MIC 32 uM), and C. albicans (MIC 64 uM).
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
700 µM
Hemolytic Cytotoxic
50% Hemolysis | 700 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae). | Regul Pept | 2008
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
2010 µM
Hemolytic Cytotoxic
50% Hemolysis | 2010 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Study on the Structure-Activity Relationship of an Antimicrobial Peptide, Brevinin-2GUb, from the Skin Secretion of Hylarana guentheri. | Antibiotics (Basel) | 2021
Evidence 12 Activity

Activity

IC50
Toxicity
68 µM
Cytotoxic
IC50 | 68 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Study on the Structure-Activity Relationship of an Antimicrobial Peptide, Brevinin-2GUb, from the Skin Secretion of Hylarana guentheri. | Antibiotics (Basel) | 2021
Evidence 13 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP