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Peptide record

TPDB11179

Antibacterial Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11179
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GAFGDLLKGVAKEAGMKLLNMAQCKLSGKC
Physicochemical Analysis
C133H229N37O38S4
RHIPTWY
GLK
3082.75
9.65
5
2
13
+3
3.90
0.190
88.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.05
5
Residue Composition
number
4
A
0
R
1
N
1
D
2
C
1
E
1
Q
5
G
0
H
0
I
5
L
5
K
2
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 5 H: 0 I: 0 L: 5 K: 5 M: 2 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
30
C133H229N37O38S4
3082.75
9.65
+3
3.90
0.190
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC2592 (MIC 2 uM), B. licheniformis X39 (IS) (MIC 8 uM), S. carnosus KHS (IS) (MIC 2 uM), R. rhodochrous X1
Evidence 2 Activity

Activity

MIC
Antibacterial
32.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

9 (IS) (MIC 8 uM), S. carnosus KHS (IS) (MIC 2 uM), R. rhodochrous X15 (IS) (MIC 0.5 uM), E. coli ATCC 25922 (MIC 32.5 uM), S.rubidaea X01 (IS) (MIC 130 uM), P. aeruginosa 1.50 (IS) (MIC 65 uM), P. faecalis X29 (
Evidence 3 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC2592 (MIC 2 uM), B. licheniformis X39 (IS) (MIC 8 uM), S. carnosus KHS (IS) (MIC 2 uM), R. rhodochrous X1
Evidence 4 Activity

Activity

MIC
Antifungal
32.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9 (IS) (MIC 8 uM), S. carnosus KHS (IS) (MIC 2 uM), R. rhodochrous X15 (IS) (MIC 0.5 uM), E. coli ATCC 25922 (MIC 32.5 uM), S.rubidaea X01 (IS) (MIC 130 uM), P. aeruginosa 1.50 (IS) (MIC 65 uM), P. faecalis X29 (
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
520 µM
Hemolytic Cytotoxic
50% Hemolysis | 520 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii | Biochimie | 2012
Evidence 6 Activity

Activity

LD50
Toxicity
520 µM
Hemolytic
Hemolytic_activity: [Ref.22426384] LD50=520 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Jun 94(6):1317-1326.