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Peptide record

TPDB11178

Cliotide T1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11178
Cliotide T1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIPCGESCVFIPCITGAIGCSCKSKVCYRN
Physicochemical Analysis
C131H214N36O39S6
DQHLMW
C
3109.72
8.02
3
1
9
+2
1.92
0.583
74.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
59.97
12
Residue Composition
number
1
A
1
R
1
N
0
D
6
C
1
E
0
Q
4
G
0
H
4
I
0
L
2
K
0
M
1
F
2
P
3
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 4 L: 0 K: 2 M: 0 F: 1 P: 2 S: 3 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C131H214N36O39S6
3109.72
8.02
+2
1.92
0.583
Free
L
Not Available
Free
Antibacterial
Clitoria ternatea
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.1 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not
Evidence 2 Activity

Activity

MIC
Antibacterial
2.7 µM

Target

K. pneumonia

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD
Evidence 3 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD owing to the lack of activity d
Evidence 4 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

MIC
Antifungal
1.1 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not
Evidence 6 Activity

Activity

MIC
Antifungal
2.7 µM

Target

K. pneumonia

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD
Evidence 7 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD owing to the lack of activity d
Evidence 8 Activity

Activity

MIC
Antiparasitic
1.1 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not
Evidence 9 Activity

Activity

MIC
Antiparasitic
2.7 µM

Target

K. pneumonia

Source & Reference

DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD
Evidence 10 Activity

Activity

MIC
Antiparasitic
4.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD owing to the lack of activity d
Evidence 11 Activity

Activity

MIC
Antiviral
1.1 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not
Evidence 12 Activity

Activity

MIC
Antiviral
2.7 µM

Target

K. pneumonia

Source & Reference

DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD
Evidence 13 Activity

Activity

MIC
Antiviral
4.7 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 1.1 uM), K. pneumonia (MIC 2.7 uM), and P. aeruginosa (MIC 4.7 uM). Cliotides T5 to T12 have not been collected into the APD owing to the lack of activity d
Evidence 14 Activity

Activity

HD50
Hemolysis
8.4 µM
[Ref.21596752] HD50 = 8.4 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2011 Jul 8 286(27):24275-24287.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
7.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 7.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. | J Biol Chem | 2011
Evidence 16 Activity

Activity

HD50
Toxicity
8.4 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.21596752] HD50 = 8.4 µM against human red blood cells | Cytotoxicity: [Ref.21596752] IC50=0.6 µM against HeLa cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
Evidence 17 Hemolysis

Activity

8.4 µM
HD50
[Ref.21596752] HD50 = 8.4 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.