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Peptide record

TPDB11177

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB11177
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C163H280N50O44
ACHMWY
K
3644.32
11.12
10
4
9
+6
14.16
-1.053
84.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
4
R
1
N
1
D
0
C
3
E
1
Q
1
G
0
H
3
I
2
L
6
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 0 E: 3 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 6 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
30
C163H280N50O44
3644.32
11.12
+6
14.16
-1.053
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. albicans and susceptible strain S. aureus mprF (KO).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against C. albicans and susceptible strain S. aureus mprF (KO).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against C. albicans and susceptible strain S. aureus mprF (KO).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against C. albicans and susceptible strain S. aureus mprF (KO).
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
23 %
[Ref.14978112]23% hemolytic activity at 88 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Immunol 2004 172: 3070-3077.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

23% Hemolysis
Toxicity
88 µM
Hemolytic Cytotoxic
23% Hemolysis | 88 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. | J Immunol | 2004
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.14978112]23% hemolytic activity at 88 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Immunol 2004 172: 3070-3077.
Evidence 8 Hemolysis

Activity

23 %
% Hemolysis
[Ref.14978112]23% hemolytic activity at 88 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Immunol 2004 172: 3070-3077.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.