TPDB11169

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.64 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabi

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.3 µM

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

st E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.2-10.3 µM

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM), S. paratyphi A (1.3 uM), Gram+ S. aureus ATCC25923 (1.3 uM), B. cereus (2.6 uM), B. subt

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.64 µM

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. splendidus, E. tarda (MIC 0.64 uM), V. vulnificus, V. harveyi, V. fluvialis, V. alginolyticus, V. parahaemdyticus, (MIC 1.3-

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.59 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

guillarum (5.2 uM). This peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis,

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.29 µM

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

d activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.64 µM

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

eria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.29 µM

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.64 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

liensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM),

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.29 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.ve

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.29 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

arahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.59 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also s

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.59 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also shows antibiofilm activity

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.64 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabi

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.3 µM

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

st E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.2-10.3 µM

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM), S. paratyphi A (1.3 uM), Gram+ S. aureus ATCC25923 (1.3 uM), B. cereus (2.6 uM), B. subt

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.64 µM

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. splendidus, E. tarda (MIC 0.64 uM), V. vulnificus, V. harveyi, V. fluvialis, V. alginolyticus, V. parahaemdyticus, (MIC 1.3-

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.59 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

guillarum (5.2 uM). This peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis,

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.29 µM

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

d activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.64 µM

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

eria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.29 µM

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

, V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.64 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

liensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM),

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.29 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.ve

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.29 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

arahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.59 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

, V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also s

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.59 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also shows antibiofilm activity

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.64 µM

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabi

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.3 µM

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

st E. coli ATCC25922 (MIC 0.64 uM), S. dysenteriae (0.16 uM), K. pneumoniae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 5.2-10.3 µM

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

ae (1.29-21 uM), K. oxytoca (MIC 1.3 uM), P. mirabilis (1.3 uM), S. maltophilia (2.6 uM), P. aeruginosa ATCC27853 (MIC 5.2-10.3 uM), S. paratyphi A (1.3 uM), Gram+ S. aureus ATCC25923 (1.3 uM), B. cereus (2.6 uM), B. subt

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.64 µM

Target

Target Organism E. tarda

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. splendidus, E. tarda (MIC 0.64 uM), V. vulnificus, V. harveyi, V. fluvialis, V. alginolyticus, V. parahaemdyticus, (MIC 1.3-

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.59 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

guillarum (5.2 uM). This peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis,

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.29 µM

Target

Target Organism V. brasiliensis

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

d activity against aquatic bacteria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.64 µM

Target

Target Organism V. cholerae

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

eria Gram- V. alginolyticus (MIC 2.59 uM), V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.29 µM

Target

Target Organism V. harveyi

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

, V. anguillarum, V. brasiliensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.64 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

liensis (MIC 1.29 uM), V. cholerae (MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM),

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.29 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

(MIC 0.64 uM), V. fluvialis, V. harveyi (MIC 1.29 uM), V. parahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.ve

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.29 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

arahaemolyticus (MIC 0.64 uM), V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.59 µM

Target

Target Organism A. sobria

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

, V. splendidus (MIC 1.29 uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also s

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.59 µM

Target

Target Organism A.veronii

Source & Reference

Database Source DRAMP DRAVP 2.0

Other

Evidence Text

uM), V. vulnificus. (MIC 2.59 uM), A. hydrophila (MIC 1.29 uM), A. sobria (MIC 2.59 uM), A.veronii (MIC 2.59 uM), and N. asteroides (MIC 1.29) ( Ouyang et al., 2022 ). It also shows antibiofilm activity

Evidence 40 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity, and Special Mechanism. | J Biol Chem | 2015

Evidence 41 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity, and Special Mechanism. | J Biol Chem | 2015

Evidence 42 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 5.25 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: [Ref.26013823]5.25% Hemolysis against Human erythrocytes at 200 µg/ml(55.12 µM). | Cytotoxicity: [Ref.26013823]4.70% cell death at 200 µg/ml against Human hepatocellular carcinoma HepG2 3.63% cell death at 200 µg/ml against Human prostate adenocarcinoma PC-3 1.30% cell death at 200 µg/ml against Mouse fibroblasts L929.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2015 Jul 3 290(27):16633-52.