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Peptide record

TPDB11161

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11161
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AWLDKLKSLGKVVGKVALGVAQNYLNPQQ
Physicochemical Analysis
C144H237N39O39
RCEHIMFT
L
3138.70
10.31
4
1
14
+3
2.56
-0.041
117.59
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
222.70
7
Residue Composition
number
3
A
0
R
2
N
1
D
0
C
0
E
3
Q
3
G
0
H
0
I
5
L
4
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 3 G: 3 H: 0 I: 0 L: 5 K: 4 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 4
Chemical Descriptors
29
C144H237N39O39
3138.70
10.31
+3
2.56
-0.041
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, in
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, including Rsp-2, Rsp-3, Rsp-4
Evidence 4 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other
Evidence 5 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, in
Evidence 6 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, including Rsp-2, Rsp-3, Rsp-4
Evidence 7 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other
Evidence 8 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, in
Evidence 9 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 10 uM), and S. aureus (MIC 20 uM). Antimicrobial activities for other peptides in the family, including Rsp-2, Rsp-3, Rsp-4
Evidence 10 Activity

Activity

% Hemolysis
Hemolysis
20 %
[Ref.18976634]20% hemolytic activity at 80 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 2008 Dec 26 377(4):1057-1061.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

20% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
20% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps. | Biochem Biophys Res Commun | 2008
Evidence 12 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.18976634]20% hemolytic activity at 80 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2008 Dec 26 377(4):1057-1061.
Evidence 13 Hemolysis

Activity

20 %
% Hemolysis
[Ref.18976634]20% hemolytic activity at 80 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochem Biophys Res Commun. 2008 Dec 26 377(4):1057-1061.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.