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Peptide record

TPDB11160

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11160
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RVKRFWPLVPVAINTVAAGINLYKAIRRK
Physicochemical Analysis
C157H261N47O34
DCEQHMS
ARV
3351.09
12.42
7
0
16
+7
1.73
0.162
121.03
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
208.59
4
Residue Composition
number
4
A
4
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
3
K
0
M
1
F
2
P
0
S
1
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 1 V: 4
Chemical Descriptors
29
C157H261N47O34
3351.09
12.42
+7
1.73
0.162
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Escherichia coli PCN033 or RS218

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli PCN033 or RS218 (MIC 5-10 uM),
Evidence 2 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Escherichia coli PCN033 or RS218

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli PCN033 or RS218 (MIC 5-10 uM),
Evidence 3 Activity

Activity

MIC
Antiparasitic
5-10 µM

Target

Escherichia coli PCN033 or RS218

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli PCN033 or RS218 (MIC 5-10 uM),
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides | bioRxiv | 2024