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Peptide record

TPDB11159

Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11159
Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
RKCNFLCKLKEKLRTVITSHIDKVLRPQG
Physicochemical Analysis
C151H263N47O39S2
AMWY
K
3425.16
10.69
9
2
9
+6
9.13
-0.483
100.69
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
3.65
7
Residue Composition
number
0
A
3
R
1
N
1
D
2
C
1
E
1
Q
1
G
1
H
2
I
4
L
5
K
0
M
1
F
1
P
1
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 1 H: 1 I: 2 L: 4 K: 5 M: 0 F: 1 P: 1 S: 1 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C151H263N47O39S2
3425.16
10.69
+6
9.13
-0.483
Evidence Records 6 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
2.5 5.5 %
[Ref.23594231]2.5% hemolytic activity at 12.5 µg/mL, 3.5 hemolytic activity at 25 µg/mL, 5.5% hemolytic activity at 50 µg/mL against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Med Chem. 2013 May 9 56(9):3546-56.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

3% Hemolysis
Toxicity
12.5 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 12.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide. | J Med Chem | 2013
Evidence 3 Activity

Activity

4% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide. | J Med Chem | 2013
Evidence 4 Activity

Activity

6% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide. | J Med Chem | 2013
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23594231]2.5% hemolytic activity at 12.5 µg/mL, 3.5 hemolytic activity at 25 µg/mL, 5.5% hemolytic activity at 50 µg/mL against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2013 May 9 56(9):3546-56.
Evidence 6 Hemolysis

Activity

2.5 5.5 %
% Hemolysis
[Ref.23594231]2.5% hemolytic activity at 12.5 µg/mL, 3.5 hemolytic activity at 25 µg/mL, 5.5% hemolytic activity at 50 µg/mL against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Med Chem. 2013 May 9 56(9):3546-56.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.