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Peptide record

TPDB11156

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11156
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb AVPpred-BWR APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IKLSPETKDNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
C139H251N37O37S1
RCQHFWY
K
3064.81
10.65
7
2
14
+5
8.03
0.169
124.48
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
4
A
0
R
1
N
1
D
0
C
1
E
0
Q
2
G
0
H
3
I
3
L
7
K
1
M
0
F
1
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 7 M: 1 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
29
C139H251N37O37S1
3064.81
10.65
+5
8.03
0.169
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20-40 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
e showed woderate activity against Gram-negative bacteria such as E. coli, P. Aeruginosa, K. pneumoniae (MIC 20-40 uM), and good activity against S. aureus (10 uM). This peptide stimulate insulin release in v
Evidence 2 Activity

Activity

MIC
Antifungal
20-40 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
e showed woderate activity against Gram-negative bacteria such as E. coli, P. Aeruginosa, K. pneumoniae (MIC 20-40 uM), and good activity against S. aureus (10 uM). This peptide stimulate insulin release in v
Evidence 3 Activity

Activity

MIC
Antiparasitic
20-40 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
e showed woderate activity against Gram-negative bacteria such as E. coli, P. Aeruginosa, K. pneumoniae (MIC 20-40 uM), and good activity against S. aureus (10 uM). This peptide stimulate insulin release in v
Evidence 4 Activity

Activity

MIC
Antiviral
20-40 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
e showed woderate activity against Gram-negative bacteria such as E. coli, P. Aeruginosa, K. pneumoniae (MIC 20-40 uM), and good activity against S. aureus (10 uM). This peptide stimulate insulin release in v
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
5 6.3 7.7 10 10.7 15.3 9 15 9.7 %
[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0µM

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
ACS Chem Biol. 2019 Mar 15 14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
225 µM
Hemolytic Cytotoxic
50% Hemolysis | 225 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The hymenochirins: a family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae). | Peptides | 2012
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
9.7 %
Hemolytic
Hemolytic_activity: [Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Mar 15 14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.
Evidence 8 Hemolysis

Activity

5 6.3 7.7 10 10.7 15.3 9 15 9.7 %
% Hemolysis
[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0µM
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
ACS Chem Biol. 2019 Mar 15 14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.