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Peptide record

TPDB11154

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11154
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLPVCGETCTLGTCYTQGCTCSWPICKRN
Physicochemical Analysis
C128H204N36O41S6
ADHMF
C
3095.60
7.62
2
1
6
+1
1.00
0.038
50.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
237.92
15
Residue Composition
number
0
A
1
R
1
N
0
D
6
C
1
E
1
Q
4
G
0
H
1
I
2
L
1
K
0
M
0
F
2
P
1
S
5
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 1 G: 4 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 2 S: 1 T: 5 W: 1 Y: 1 V: 1
Chemical Descriptors
29
C128H204N36O41S6
3095.60
7.62
+1
1.00
0.038
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
160 µM

Target

E.coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömste
Evidence 2 Activity

Activity

MIC
Antibacterial
1.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 3 Activity

Activity

MIC
Antibacterial
>160 µM

Target

S.aureus

Source & Reference

dbAMP

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 4 Activity

Activity

MIC
Antibacterial
>160 µM

Target

C.albicans

Source & Reference

dbAMP

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 5 Activity

Activity

MIC
Antifungal
160 µM

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömste
Evidence 6 Activity

Activity

MIC
Antifungal
1.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 7 Activity

Activity

MIC
Antifungal
>160 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 8 Activity

Activity

MIC
Antifungal
>160 µM

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 9 Activity

Activity

MIC
Antiparasitic
160 µM

Target

E.coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömste
Evidence 10 Activity

Activity

MIC
Antiparasitic
1.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 11 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 12 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

C.albicans

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 13 Activity

Activity

MIC
Antiviral
160 µM

Target

E.coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömste
Evidence 14 Activity

Activity

MIC
Antiviral
1.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 15 Activity

Activity

MIC
Antiviral
>160 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 16 Activity

Activity

MIC
Antiviral
>160 µM

Target

C.albicans

Source & Reference

dbAMP 3.0

Other

active against E.coli (MIC 160 uM), P. aeruginosa (MIC 1.25 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ).
Evidence 17 Activity

Activity

HD50
Hemolysis
55.2
[Ref.20564013] HD50=55.2±1.3 µM against Human red blood cells .

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Chembiochem. 2007 Jun 18 8(9):1001-1011.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
55.2±1.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 55.2±1.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. | Biopolymers | 2010
Evidence 19 Activity

Activity

HD50
Toxicity
55.2
Hemolytic
Hemolytic_activity: [Ref.20564013] HD50=55.2±1.3 µM against Human red blood cells .

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2007 Jun 18 8(9):1001-1011.
Evidence 20 Hemolysis

Activity

55.2
HD50
[Ref.20564013] HD50=55.2±1.3 µM against Human red blood cells .
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Chembiochem. 2007 Jun 18 8(9):1001-1011.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.