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Peptide record

TPDB11152

Varv peptide A Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11152
Varv peptide A
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP AI4AVP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
GLPVCGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
C116H185N35O40S6
ADQHIKMFY
C
2902.32
5.90
1
1
5
-0
2.25
0.148
43.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
202.42
14
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
0
Q
5
G
0
H
0
I
1
L
0
K
0
M
0
F
3
P
2
S
4
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 2 T: 4 W: 1 Y: 0 V: 3
Chemical Descriptors
29
C116H185N35O40S6
2902.32
5.90
-0
2.25
0.148
Free
L
Not Available
Free
Anticancer
Viola arvensis,Viola odorata, Viola tricolor, Viola baoshanensis, Viola yedoensis, and Viola biflora
Evidence Records 44 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>160 µM

Target

E.coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömst
Evidence 2 Activity

Activity

MIC
Antibacterial
80 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, p
Evidence 3 Activity

Activity

MIC
Antibacterial
>160 µM

Target

S.aureus

Source & Reference

dbAMP

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (M
Evidence 4 Activity

Activity

MIC
Antibacterial
>160 µM

Target

C.albicans

Source & Reference

dbAMP

Other

ctive against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
80 µM

Target

B. cinerea

Source & Reference

dbAMP

Other

(MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. al
Evidence 6 Activity

Activity

MIC
Antibacterial
40 µM

Target

F. graminearum

Source & Reference

dbAMP

Other

icans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slaz
Evidence 7 Activity

Activity

MIC
Antibacterial
40 µM

Target

F. culmorum

Source & Reference

dbAMP

Other

edt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

C. utrechtense

Source & Reference

dbAMP

Other

plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 9 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

A. alternatam

Source & Reference

dbAMP

Other

0 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 10 Activity

Activity

Not Available
Anticancer

Target

Fibrosarcoma
Not Available
Fibrous connective tissue

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1998

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 11 Activity

Activity

MIC
Antifungal
>160 µM

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömst
Evidence 12 Activity

Activity

MIC
Antifungal
80 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, p
Evidence 13 Activity

Activity

MIC
Antifungal
>160 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (M
Evidence 14 Activity

Activity

MIC
Antifungal
>160 µM

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ctive against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MI
Evidence 15 Activity

Activity

MIC
Antifungal
80 µM

Target

B. cinerea

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. al
Evidence 16 Activity

Activity

MIC
Antifungal
40 µM

Target

F. graminearum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

icans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slaz
Evidence 17 Activity

Activity

MIC
Antifungal
40 µM

Target

F. culmorum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

edt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated
Evidence 18 Activity

Activity

MIC
Antifungal
6.25 µM

Target

C. utrechtense

Source & Reference

dbAMP CAFPdb Antifungipept

Other

plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 19 Activity

Activity

MIC
Antifungal
1.5 µM

Target

A. alternatam

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 20 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

E.coli

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömst
Evidence 21 Activity

Activity

MIC
Antiparasitic
80 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, p
Evidence 22 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

S.aureus

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (M
Evidence 23 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

C.albicans

Source & Reference

NA

Other

ctive against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MI
Evidence 24 Activity

Activity

MIC
Antiparasitic
80 µM

Target

B. cinerea

Source & Reference

NA

Other

(MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. al
Evidence 25 Activity

Activity

MIC
Antiparasitic
40 µM

Target

F. graminearum

Source & Reference

NA

Other

icans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slaz
Evidence 26 Activity

Activity

MIC
Antiparasitic
40 µM

Target

F. culmorum

Source & Reference

NA

Other

edt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated
Evidence 27 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

C. utrechtense

Source & Reference

NA

Other

plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 28 Activity

Activity

MIC
Antiparasitic
1.5 µM

Target

A. alternatam

Source & Reference

NA

Other

0 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 29 Activity

Activity

MIC
Antiviral
>160 µM

Target

E.coli

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömst
Evidence 30 Activity

Activity

MIC
Antiviral
80 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, p
Evidence 31 Activity

Activity

MIC
Antiviral
>160 µM

Target

S.aureus

Source & Reference

NA

Other

Active against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (M
Evidence 32 Activity

Activity

MIC
Antiviral
>160 µM

Target

C.albicans

Source & Reference

NA

Other

ctive against E.coli (MIC>160 uM), P. aeruginosa (MIC 80 uM), S.aureus (MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MI
Evidence 33 Activity

Activity

MIC
Antiviral
80 µM

Target

B. cinerea

Source & Reference

NA

Other

(MIC >160 uM), and C.albicans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. al
Evidence 34 Activity

Activity

MIC
Antiviral
40 µM

Target

F. graminearum

Source & Reference

NA

Other

icans (MIC>160 uM) ( Strömstedt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slaz
Evidence 35 Activity

Activity

MIC
Antiviral
40 µM

Target

F. culmorum

Source & Reference

NA

Other

edt et al., 2017 ). Also, plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated
Evidence 36 Activity

Activity

MIC
Antiviral
6.25 µM

Target

C. utrechtense

Source & Reference

NA

Other

plant fungi B. cinerea (MIC 80 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 37 Activity

Activity

MIC
Antiviral
1.5 µM

Target

A. alternatam

Source & Reference

NA

Other

0 uM), F. graminearum (MIC 40 uM), F. culmorum (MIC 40 uM), C. utrechtense (MIC 6.25 uM), A. alternatam (MIC 1.5 uM) ( Slazak et al. 2018 ). Updated 8/2019 7/2021
Evidence 38 Activity

Activity

IC50
Toxicity
12.13 µM
Cytotoxic
IC50 | 12.13 | µM | target cell: Human lymphocytes

Target

Human lymphocytes

Source & Reference

NA
DBAASP
Cyclotides: a novel type of cytotoxic agents. | Mol Cancer Ther | 2002
Evidence 39 Activity

Activity

45% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
45% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. | Biochem J | 2006
Evidence 40 Activity

Activity

IC50
Toxicity
2.38±0.09 µM
Cytotoxic
IC50 | 2.38±0.09 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Isolation and characterization of cytotoxic cyclotides from Viola philippica. | Peptides | 2011
Evidence 41 Activity

Activity

50% hemolysis
Toxicity
31.0±2.7 µM
Hemolytic Cytotoxic
50% hemolysis | 31.0±2.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. | Chembiochem | 2014
Evidence 42 Activity

Activity

50% Cell death
Toxicity
8.4±1.3 µM
Cytotoxic
50% Cell death | 8.4±1.3 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. | Chembiochem | 2014
Evidence 43 Activity

Activity

IC50
Toxicity
37.8 µg/mL
Cytotoxic
Cytotoxicity: [Ref.20580652] Cytotoxicity: U251(IC50 = 37.8µg/mL), MDA-MB-231(IC50>10µg/mL), A549(IC50>10µg/mL), DU145(IC50>10µg/mL), BEL-7402(IC50>10µg/mL).##[Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 6µM) and RPMI-8226/s (myeloma)(IC50 = 3µM).

Source & Reference

NA
DRAMP
Peptides . 2010 Aug 31(8):1434-1440.##J Nat Prod. 2004 Feb 67(2):144-147.##Mol Cancer Ther . 2002 Apr 1(6):365-9.
Evidence 44 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.