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Peptide record

TPDB11151

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11151
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP dbAMP 3.0 AI4AVP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GLPVCGETCFGGTCNTPGCSCTWPICTRD
Physicochemical Analysis
C122H188N34O41S6
AQHKMY
C
2979.40
4.07
1
2
5
-1
1.49
0.114
36.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
197.19
13
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
1
E
0
Q
5
G
0
H
1
I
1
L
0
K
0
M
1
F
3
P
1
S
5
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 3 S: 1 T: 5 W: 1 Y: 0 V: 1
Chemical Descriptors
29
C122H188N34O41S6
2979.40
4.07
-1
1.49
0.114
Evidence Records 27 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Moderately active against S. aureus (MIC 50 uM) and also reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive
Evidence 2 Activity

Activity

MIC
Antibacterial
>160 µM

Target

E.coli

Source & Reference

dbAMP

Other

reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt
Evidence 3 Activity

Activity

MIC
Antibacterial
160 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

d in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pe
Evidence 4 Activity

Activity

MIC
Antibacterial
>160 µM

Target

S.aureus

Source & Reference

dbAMP

Other

C et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden
Evidence 5 Activity

Activity

MIC
Antibacterial
>160 µM

Target

C.albicans

Source & Reference

dbAMP

Other

inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden apple snails, serious pes
Evidence 6 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Moderately active against S. aureus (MIC 50 uM) and also reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive
Evidence 7 Activity

Activity

MIC
Antifungal
>160 µM

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt
Evidence 8 Activity

Activity

MIC
Antifungal
160 µM

Target

P.aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

d in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pe
Evidence 9 Activity

Activity

MIC
Antifungal
>160 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden
Evidence 10 Activity

Activity

MIC
Antifungal
>160 µM

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden apple snails, serious pes
Evidence 11 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Moderately active against S. aureus (MIC 50 uM) and also reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive
Evidence 12 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

E.coli

Source & Reference

dbAMP 3.0

Other

reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt
Evidence 13 Activity

Activity

MIC
Antiparasitic
160 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0

Other

d in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pe
Evidence 14 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

C et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden
Evidence 15 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

C.albicans

Source & Reference

dbAMP 3.0

Other

inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden apple snails, serious pes
Evidence 16 Activity

Activity

MIC
Antiviral
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Moderately active against S. aureus (MIC 50 uM) and also reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive
Evidence 17 Activity

Activity

MIC
Antiviral
>160 µM

Target

E.coli

Source & Reference

dbAMP 3.0

Other

reduced bacterial load in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt
Evidence 18 Activity

Activity

MIC
Antiviral
160 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0

Other

d in vivo ( Fensterseifer IC et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pe
Evidence 19 Activity

Activity

MIC
Antiviral
>160 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

C et al., 2014 ). Also, inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden
Evidence 20 Activity

Activity

MIC
Antiviral
>160 µM

Target

C.albicans

Source & Reference

dbAMP 3.0

Other

inactive against E.coli (MIC >160 uM), P.aeruginosa (MIC 160 uM), S.aureus (MIC >160 uM), C.albicans (MIC >160 uM) ( Strömstedt et al., 2017 ). Natural pesticide: Toxic to Golden apple snails, serious pes
Evidence 21 Activity

Activity

HD50
Hemolysis
3.3
[Ref.20564013] HD50=3.3±1.9 µM against Human red blood cells .

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Biochemistry. 2005 Jan 25 44(3):851-860.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers . 2010 94(5):647-58.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
3.3±1.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 3.3±1.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. | Biopolymers | 2010
Evidence 23 Activity

Activity

50% Hemolysis
Toxicity
11.5±0.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.5±0.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 24 Activity

Activity

50% Cell death
Toxicity
1.5±0.1 µM
Cytotoxic
50% Cell death | 1.5±0.1 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 25 Activity

Activity

50% Cell death
Toxicity
6.4±0.4 µM
Cytotoxic
50% Cell death | 6.4±0.4 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014
Evidence 26 Activity

Activity

HD50
Toxicity
3.3
Hemolytic
Hemolytic_activity: [Ref.20564013] HD50=3.3±1.9 µM against Human red blood cells .

Target

erythrocytes

Source & Reference

NA
DRAMP
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Biochemistry. 2005 Jan 25 44(3):851-860.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers . 2010 94(5):647-58.
Evidence 27 Hemolysis

Activity

3.3
HD50
[Ref.20564013] HD50=3.3±1.9 µM against Human red blood cells .
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Mol Biol. 1999 Dec 17 294(5):1327-1336.##Biochemistry. 2005 Jan 25 44(3):851-860.##Chembiochem. 2007 Jun 18 8(9):1001-1011.##Biopolymers . 2010 94(5):647-58.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.