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Peptide record

TPDB11150

Cliotide T3 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11150
Cliotide T3
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLPTCGETCTLGTCYVPDCSCSWPICMKN
Physicochemical Analysis
C128H200N32O42S7
ARQHF
C
3083.61
4.07
1
2
7
-1
1.04
0.214
50.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
238.84
14
Residue Composition
number
0
A
0
R
1
N
1
D
6
C
1
E
0
Q
3
G
0
H
1
I
2
L
1
K
1
M
0
F
3
P
2
S
4
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 1 M: 1 F: 0 P: 3 S: 2 T: 4 W: 1 Y: 1 V: 1
Chemical Descriptors
29
C128H200N32O42S7
3083.61
4.07
-1
1.04
0.214
Free
L
Not Available
Free
Antibacterial
Clitoria ternatea
Evidence Records 5 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

HD50
Hemolysis
13.1 µM
[Ref:21596752] HD50=13.1 µM against human type A erythrocytes

Target

human type A erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2011 Jul 8 286(27):24275-24287.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
13.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 13.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. | J Biol Chem | 2011
Evidence 4 Activity

Activity

HD50
Toxicity
13.1 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:21596752] HD50=13.1 µM against human type A erythrocytes | Cytotoxicity: [Ref.21596752] Cytotoxicity: HeLa Cells (IC50=2.0 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
Evidence 5 Hemolysis

Activity

13.1 µM
HD50
[Ref:21596752] HD50=13.1 µM against human type A erythrocytes
Hemolysis

Target

human type A erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2011 Jul 8 286(27):24275-24287.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.