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Peptide record

TPDB11148

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11148
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFMDTAKNVAKNVAATLLDKLKCKITGGC
Physicochemical Analysis
C130H224N36O39S3
REQHPSWY
K
3011.61
9.65
5
2
12
+3
4.33
0.152
87.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.15
7
Residue Composition
number
4
A
0
R
2
N
2
D
2
C
0
E
0
Q
3
G
0
H
1
I
3
L
5
K
1
M
1
F
0
P
0
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 2 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 5 M: 1 F: 1 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C130H224N36O39S3
3011.61
9.65
+3
4.33
0.152
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
14.5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- bacteria E. coli (MIC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
7.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

IC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al
Evidence 3 Activity

Activity

MIC
Antibacterial
14.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

lled P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.aurues MRSA-inactive

Source & Reference

dbAMP DRAMP

Other

l. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

ive against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 8 Activity

Activity

MIC
Antifungal
14.5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- bacteria E. coli (MIC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 9 Activity

Activity

MIC
Antifungal
7.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al
Evidence 10 Activity

Activity

MIC
Antifungal
14.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lled P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active
Evidence 11 Activity

Activity

MIC
Antifungal
100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C
Evidence 12 Activity

Activity

MIC
Antifungal
>100 µM

Target

S.aurues MRSA-inactive

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 13 Activity

Activity

MIC
Antifungal
12.5 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ive against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 15 Activity

Activity

MIC
Antiparasitic
14.5 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- bacteria E. coli (MIC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 16 Activity

Activity

MIC
Antiparasitic
7.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

IC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al
Evidence 17 Activity

Activity

MIC
Antiparasitic
14.5 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

lled P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active
Evidence 18 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C
Evidence 19 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

S.aurues MRSA-inactive

Source & Reference

DRAMP

Other

l. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 20 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

ive against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 21 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

C.albicans

Source & Reference

DRAMP

Other

), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 22 Activity

Activity

MIC
Antiviral
14.5 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram- bacteria E. coli (MIC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 23 Activity

Activity

MIC
Antiviral
7.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

IC 14.5 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al
Evidence 24 Activity

Activity

MIC
Antiviral
14.5 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

lled P. aeruginosa) (MIC 14.5 ug/ml), Gram+ bacteria S. aureus (MIC 7.3 ug/ml), and yeast C. albicans (MIC 14.5 ug/ml). Found in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active
Evidence 25 Activity

Activity

MIC
Antiviral
100 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

in multiple species. Also see Yang X et al. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C
Evidence 26 Activity

Activity

MIC
Antiviral
>100 µM

Target

S.aurues MRSA-inactive

Source & Reference

DRAMP

Other

l. 2011 J Proteome Res. in press. Active against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 27 Activity

Activity

MIC
Antiviral
12.5 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

ive against E. coli (MIC 100 uM), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.
Evidence 28 Activity

Activity

MIC
Antiviral
>100 µM

Target

C.albicans

Source & Reference

DRAMP

Other

), S. aureus (25 uM), S.aurues MRSA-inactive (MIC>100 uM), B. subtilis (MIC 12.5 uM), and C.albicans (MIC>100 uM). Data conflict.