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Peptide record

TPDB11147

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11147
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SIGSALKKALPVAKKIGKIALPIAKAALP
Physicochemical Analysis
C135H243N35O32
RNDCEQHMFTWY
A
2868.63
11.21
6
0
16
+6
2.97
0.669
141.72
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
4
I
4
L
6
K
0
M
0
F
3
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 4 L: 4 K: 6 M: 0 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
29
C135H243N35O32
2868.63
11.21
+6
2.97
0.669
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Ctx A was active against Gram-negative E. coli ( Marri et al., 1996 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Ctx A was active against Gram-negative E. coli ( Marri et al., 1996 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Ctx A was active against Gram-negative E. coli ( Marri et al., 1996 ).
Evidence 4 Activity

Activity

Hemolysis
[Swiss_Prot Entry P36190]has hemolytic activity

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Insect Biochem Mol Biol. 1993 Jul 23(5):591-598.##J Biol Chem. 1995 Mar 17 270(11):6199-6204.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

100% Hemolysis
Toxicity
960 µM
Hemolytic Cytotoxic
100% Hemolysis | 960 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and pore-forming properties of ceratotoxins: a mechanism of action based on the barrel stave model. | Biochim Biophys Acta | 2004
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Swiss_Prot Entry P36190]has hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Insect Biochem Mol Biol. 1993 Jul 23(5):591-598.##J Biol Chem. 1995 Mar 17 270(11):6199-6204.
Evidence 7 Hemolysis

Activity

[Swiss_Prot Entry P36190]has hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Insect Biochem Mol Biol. 1993 Jul 23(5):591-598.##J Biol Chem. 1995 Mar 17 270(11):6199-6204.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.