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Peptide record

TPDB11146

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11146
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFISTVKNLATNVAGTVIDTIKCKVTGGC
Physicochemical Analysis
C126H216N34O40S2
REQHMPWY
T
2911.42
9.08
3
1
11
+2
2.75
0.600
100.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.29
10
Residue Composition
number
2
A
0
R
2
N
1
D
2
C
0
E
0
Q
4
G
0
H
3
I
1
L
3
K
0
M
1
F
0
P
1
S
5
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 1 K: 3 M: 0 F: 1 P: 0 S: 1 T: 5 W: 0 Y: 0 V: 4
Chemical Descriptors
29
C126H216N34O40S2
2911.42
9.08
+2
2.75
0.600
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
110 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012
Evidence 2 Activity

Activity

MIC
Antibacterial
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012 5/2020 GW 7/2021
Evidence 3 Activity

Activity

MIC
Antifungal
110 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012
Evidence 4 Activity

Activity

MIC
Antifungal
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012 5/2020 GW 7/2021
Evidence 5 Activity

Activity

MIC
Antiparasitic
110 µM

Target

E.coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012
Evidence 6 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Weakly active againt E.coli (MIC 110 uM), not S.aureus or C.albicans (MIC >200 uM). Found in multiple species. APD Updated 8/2012 5/2020 GW 7/2021
Evidence 7 Activity

Activity

HC50
Hemolysis
300 µM
[Ref.12429503] HC50>300 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata. | Biochim Biophys Acta | 2002
Evidence 9 Activity

Activity

HC50
Toxicity
300 µM
Hemolytic
Hemolytic_activity: [Ref.12429503] HC50>300 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
Evidence 10 Hemolysis

Activity

300 µM
HC50
[Ref.12429503] HC50>300 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.