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Peptide record

TPDB11143

HNP-2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11143
HNP-2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF Antifungipept CAFPdb AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
C147H223N43O37S6
NDHKMSV
C
3377.01
8.30
4
1
12
+3
-2.78
0.248
64.14
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
10345
306.34
11
Residue Composition
number
3
A
4
R
0
N
0
D
6
C
1
E
1
Q
3
G
0
H
3
I
1
L
0
K
0
M
1
F
1
P
0
S
1
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 0 I: 3 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 3 V: 0
Chemical Descriptors
29
C147H223N43O37S6
3377.01
8.30
+3
-2.78
0.248
Free
L
Not Available
Free
Anticancer
Homo sapiens
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-1 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Fibrosarcoma
Not Available
Fibrous connective tissue

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1985

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-1 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types).
Evidence 4 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-1 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types).
Evidence 5 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Activity against E. coli CIP 76.24, P. aeruginosa CIP 76.110 (MIC 1ug/ml), Y. enterocolitica CIP 80.27, S. aureus ATCC 29213 and S. epidermidis CIP 68.21 (MIC 0.5ug/ml). Human HNP-1 blocks papillomavirus infection (both cutaneous and mucosal papillomavirus types).
Evidence 6 Activity

Activity

1% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000