Back to search

Peptide record

TPDB11136

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11136
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
LKLSPKTKDTLKKVLKGAIKGAIAIASMA
Physicochemical Analysis
C136H248N36O36S1
RNCEQHFWY
K
2995.74
10.92
7
1
14
+6
4.99
0.262
121.38
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
5
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
7
K
1
M
0
F
1
P
2
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 7 M: 1 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
29
C136H248N36O36S1
2995.74
10.92
+6
4.99
0.262
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.6-5 µM

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
, including multiple S. aureus, S. epidermidis, A. baumannii strains, E. coli ATCC 25726, S. maltophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

S. epidermidis, A. baumannii strains, E. coli ATCC 25726, S. maltophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albi
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

altophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albicans (MIC 80 uM). Also active against human non-small lung ade
Evidence 4 Activity

Activity

MIC
Antibacterial
80 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albicans (MIC 80 uM). Also active against human non-small lung adenocarcinoma A549 cells, breast adenocarcinom
Evidence 5 Activity

Activity

MIC
Antifungal
0.6-5 µM

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
, including multiple S. aureus, S. epidermidis, A. baumannii strains, E. coli ATCC 25726, S. maltophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853
Evidence 6 Activity

Activity

MIC
Antifungal
10 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. epidermidis, A. baumannii strains, E. coli ATCC 25726, S. maltophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albi
Evidence 7 Activity

Activity

MIC
Antifungal
20 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

altophilia (MIC 0.6-5 uM), K. pneumoniae ATCC 700603 (MIC 10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albicans (MIC 80 uM). Also active against human non-small lung ade
Evidence 8 Activity

Activity

MIC
Antifungal
80 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

10 uM), E. faecalis ATCC 29212, P. aeruginosa ATCC 27853 (MIC 20 uM), and weakly against C. albicans (MIC 80 uM). Also active against human non-small lung adenocarcinoma A549 cells, breast adenocarcinom
Evidence 9 Activity

Activity

LC50
Hemolysis
162
Human red blood cells (RBC): LC50=162±13 µM

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 2014 Nov 61:114-21.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

IC50
Toxicity
7.7±0.7 µM
Cytotoxic
IC50 | 7.7±0.7 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa. | Peptides | 2014
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
162±13 µM
Hemolytic Cytotoxic
50% Hemolysis | 162±13 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa. | Peptides | 2014
Evidence 12 Activity

Activity

LC50
Toxicity
162
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (RBC): LC50=162±13 µM | Cytotoxicity: HUVEC: LC50=7.7±0.7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Nov 61:114-21.
Evidence 13 Hemolysis

Activity

162
LC50
Human red blood cells (RBC): LC50=162±13 µM
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Peptides. 2014 Nov 61:114-21.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.