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Peptide record

TPDB11135

Antibacterial Anticancer Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11135
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWNSIKIAGKKLFVNVLDKIRCKVAGGC
Physicochemical Analysis
C142H240N40O35S2
EQHMPTY
K
3131.83
10.39
6
1
13
+5
1.80
0.383
117.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
179.61
5
Residue Composition
number
2
A
1
R
2
N
1
D
2
C
0
E
0
Q
4
G
0
H
3
I
3
L
5
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 3 K: 5 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
29
C142H240N40O35S2
3131.83
10.39
+5
1.80
0.383
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM). .
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

C 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM). .
Evidence 4 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90
Evidence 5 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM). .
Evidence 6 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 1.6 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM). .
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
5.86 µM
Hemolytic Cytotoxic
10% Hemolysis | 5.86 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
33.03 µM
Hemolytic Cytotoxic
50% Hemolysis | 33.03 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022
Evidence 9 Activity

Activity

IC50
Toxicity
5.05 µM
Cytotoxic
IC50 | 5.05 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb. | Antibiotics (Basel) | 2022