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Peptide record

TPDB11134

Antibacterial Antifungal standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11134
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 29-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWDSIKIAGKKLFVNVLDKIRCKVAGGC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C142H239N39O36S2
EQHMPTY
K
3132.82
10.06
6
2
13
+4
0.46
0.383
117.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
1.80
4
Residue Composition
number
2
A
1
R
1
N
2
D
2
C
0
E
0
Q
4
G
0
H
3
I
3
L
5
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 3 K: 5 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
29 reviewed residue count
C142H239N39O36S2 sequence-only estimate (linear, free termini)
3132.82 sequence-only estimate (linear, free termini)
10.06 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.46 sequence-only estimate (linear, free termini)
0.383 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli ATCC 8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90
Evidence 2 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli ATCC 8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90
Evidence 5 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

8739 (MIC 12.5 uM), S. aureus ATCC 6538 (MIC 3.1 uM), MRSA ATCC 43300 (MIC 12.5 uM), and C. albicans ATCC 90028 (MIC 100 uM).