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Peptide record

TPDB11132

Antibacterial Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11132
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TLISWIKNKRKQRPRVSRRRRRRGGRRRR
Physicochemical Analysis
C158H290N74O35
ADCEHMFY
R
3786.52
13.48
16
0
5
+16
12.41
-2.269
50.34
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
145.25
5
Residue Composition
number
0
A
13
R
1
N
0
D
0
C
0
E
1
Q
2
G
0
H
2
I
1
L
3
K
0
M
0
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 13 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 1 K: 3 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
29
C158H290N74O35
3786.52
13.48
+16
12.41
-2.269
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
372 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 372 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses. | J Appl Microbiol | 2008
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
2500 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 2500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses. | J Appl Microbiol | 2008
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
5000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 5000 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses. | J Appl Microbiol | 2008
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
16.50 µM
Hemolytic Cytotoxic
0% Hemolysis | 16.50 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability. | PLoS One | 2019
Evidence 5 Activity

Activity

6% Hemolysis
Toxicity
264.08 µM
Hemolytic Cytotoxic
6% Hemolysis | 264.08 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability. | PLoS One | 2019
Evidence 6 Activity

Activity

17% Hemolysis
Toxicity
518.16 µM
Hemolytic Cytotoxic
17% Hemolysis | 518.16 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability. | PLoS One | 2019