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Peptide record

TPDB11126

Chassatide C10 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11126
Chassatide C10
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifp Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GEYCGESCYLIPCFTPGCYCVSRQCVNKN
Physicochemical Analysis
C137H206N36O43S6
ADHMW
C
3237.72
6.05
2
2
8
-0
2.47
-0.069
46.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
149.64
15
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
2
E
1
Q
3
G
0
H
1
I
1
L
1
K
0
M
1
F
2
P
2
S
1
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 2 Q: 1 G: 3 H: 0 I: 1 L: 1 K: 1 M: 0 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 3 V: 2
Chemical Descriptors
29
C137H206N36O43S6
3237.72
6.05
-0
2.47
-0.069
Free
L
Not Available
Free
Antibacterial
Chassalia chartacea
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Not active against E-coli, S-aureus, and S-epidermis (MIC>80 uM).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Not active against E-coli, S-aureus, and S-epidermis (MIC>80 uM).
Evidence 4 Activity

Activity

HD50
Hemolysis
25 µM
[Ref.22467870] HD50>25 µM against human type A red blood cells.

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Biol Chem. 2012 May 18 287(21):17598-17607.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>25 µM
Hemolytic Cytotoxic
50% Hemolysis | >25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. | J Biol Chem | 2012
Evidence 6 Activity

Activity

HD50
Toxicity
25 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.22467870] HD50>25 µM against human type A red blood cells. | Cytotoxicity: [Ref.22467870] Cytotoxicity: HeLa cells (IC50=5.0 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 May 18 287(21):17598-17607.
Evidence 7 Hemolysis

Activity

25 µM
HD50
[Ref.22467870] HD50>25 µM against human type A red blood cells.
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Biol Chem. 2012 May 18 287(21):17598-17607.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.