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Peptide record

TPDB11120

Antibacterial Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11120
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLWTTIKEGLKKFSLGVLDKIRCKIAGGC
Physicochemical Analysis
C142H240N38O37S2
NQHMPY
GK
3135.82
10.06
6
2
11
+4
2.74
0.221
107.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
179.38
5
Residue Composition
number
1
A
1
R
0
N
1
D
2
C
1
E
0
Q
5
G
0
H
3
I
4
L
5
K
0
M
1
F
0
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 3 L: 4 K: 5 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
29
C142H240N38O37S2
3135.82
10.06
+4
2.74
0.221
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 37.5 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (i
Evidence 2 Activity

Activity

MIC
Antibacterial
9.4 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 37.5 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 259
Evidence 3 Activity

Activity

MIC
Antibacterial
150 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP

Other

is 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 25922 (MIC 75 uM), C.albicans ATCC 10231 (inactive), and C.glabrata 090902
Evidence 4 Activity

Activity

MIC
Antibacterial
75 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 25922 (MIC 75 uM), C.albicans ATCC 10231 (inactive), and C.glabrata 090902 (inactive). Updated 5/2019 7/20
Evidence 5 Activity

Activity

MIC
Antifungal
37.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 37.5 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (i
Evidence 6 Activity

Activity

MIC
Antifungal
9.4 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 37.5 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 259
Evidence 7 Activity

Activity

MIC
Antifungal
150 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

is 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 25922 (MIC 75 uM), C.albicans ATCC 10231 (inactive), and C.glabrata 090902
Evidence 8 Activity

Activity

MIC
Antifungal
75 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (inactive), K.pneumoniae 08040724 (MIC 150 uM), E. coli ATCC 25922 (MIC 75 uM), C.albicans ATCC 10231 (inactive), and C.glabrata 090902 (inactive). Updated 5/2019 7/20
Evidence 9 Activity

Activity

100% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
100% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 10 Activity

Activity

68.4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
68.4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 11 Activity

Activity

45.4% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
45.4% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 12 Activity

Activity

35.2% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
35.2% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 13 Activity

Activity

22.8% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
22.8% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 14 Activity

Activity

13.0% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
13.0% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 15 Activity

Activity

8.4% Hemolysis
Toxicity
3.1 µM
Hemolytic Cytotoxic
8.4% Hemolysis | 3.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 16 Activity

Activity

0% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
0% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 17 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.