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Peptide record

TPDB11115

Antibacterial Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11115
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
KRNGFRKFMRRLKKFFAGGGSSIAHIKLH
Physicochemical Analysis
C155H251N51O33S1
DCEQPTWYV
K
3389.08
12.89
11
0
11
+9
4.00
-0.597
60.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
0
Q
4
G
2
H
2
I
2
L
5
K
1
M
4
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 2 I: 2 L: 2 K: 5 M: 1 F: 4 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
29
C155H251N51O33S1
3389.08
12.89
+9
4.00
-0.597
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
75 ug/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 u
Evidence 2 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

N. asteroids

Source & Reference

dbAMP

Other

am+ S. aureus ATCC25923 or MRSA (MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

B. cereus

Source & Reference

dbAMP

Other

(MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli
Evidence 4 Activity

Activity

MIC
Antibacterial
>100 ug/mL

Target

Enterococcus faecalis IS 981

Source & Reference

dbAMP

Other

S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxy
Evidence 5 Activity

Activity

MIC
Antibacterial
18.75 ug/mL

Target

E. faecium IS 1299

Source & Reference

dbAMP

Other

teroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi I
Evidence 6 Activity

Activity

MIC
Antibacterial
37.5-75 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP

Other

8 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 u
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

K.oxytoca

Source & Reference

dbAMP

Other

g/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75
Evidence 8 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

S. paratyphi IS 738

Source & Reference

dbAMP

Other

C 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC
Evidence 9 Activity

Activity

MIC
Antibacterial
2.34 µg/mL

Target

D. bacillus

Source & Reference

dbAMP

Other

922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC
Evidence 10 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP

Other

S 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) an
Evidence 11 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

(MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 12 Activity

Activity

MIC
Antibacterial
18.75-37.5 ug/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

ore), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 13 Activity

Activity

MIC
Antibacterial
37.5-75 µg/mL

Target

C. glabrata

Source & Reference

dbAMP

Other

P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 14 Activity

Activity

MIC
Antifungal
75 ug/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 u
Evidence 15 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

N. asteroids

Source & Reference

dbAMP CAFPdb Antifungipept

Other

am+ S. aureus ATCC25923 or MRSA (MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC
Evidence 16 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

B. cereus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 75 ug/mL or greater), S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli
Evidence 17 Activity

Activity

MIC
Antifungal
>100 ug/mL

Target

Enterococcus faecalis IS 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. epidermidis (MIC 75 ug/mL), N. asteroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxy
Evidence 18 Activity

Activity

MIC
Antifungal
18.75 ug/mL

Target

E. faecium IS 1299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

teroids (MIC 37.5 ug/ml), B. cereus (MIC 9.38 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi I
Evidence 19 Activity

Activity

MIC
Antifungal
37.5-75 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

8 ug/ml), E.faecalis IS 981 (MIC >100 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 u
Evidence 20 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

K.oxytoca

Source & Reference

dbAMP CAFPdb Antifungipept

Other

g/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75
Evidence 21 Activity

Activity

MIC
Antifungal
75 µg/mL

Target

S. paratyphi IS 738

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC
Evidence 22 Activity

Activity

MIC
Antifungal
2.34 µg/mL

Target

D. bacillus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

922 (MIC 37.5-75 ug/ml), K.oxytoca (MIC >100 ug/ml) , S. paratyphi IS 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC
Evidence 23 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

Stenotrophomonas maltophilia

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S 738 (MIC 75 ug/ml), D. bacillus (MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) an
Evidence 24 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 2.34 ug/ml), K. pneumoniae (MIC 75 ug/ml or more), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 25 Activity

Activity

MIC
Antifungal
18.75-37.5 ug/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ore), S. maltophilia (MIC 9.38 ug/ml), P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 26 Activity

Activity

MIC
Antifungal
37.5-75 µg/mL

Target

C. glabrata

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P.aeruginosa ATCC 27853 (MIC>100 ug/ml), and fungi C. albicans (MIC 18.75-37.5 ug/mL) and C. glabrata (MIC 37.5-75 ug/ml).
Evidence 27 Activity

Activity

7.28% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
7.28% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 28 Activity

Activity

7.5% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
7.5% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 29 Activity

Activity

6.7% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
6.7% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 30 Activity

Activity

25.28% Degranulation
Toxicity
100 µg/mL
Cytotoxic
25.28% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018