TPDB11112

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus aureus ATCC25923 or MRSA

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids

Source & Reference

Database Source dbAMP

Other

Evidence Text

st Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP

Other

Evidence Text

MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5 ug/mL

Target

Target Organism Enterococcus faecalis IS 981

Source & Reference

Database Source dbAMP

Other

Evidence Text

epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxyt

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 ug/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP

Other

Evidence Text

eroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi I

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5 µg/mL

Target

Target Organism S. paratyphi IS 738

Source & Reference

Database Source dbAMP

Other

Evidence Text

C 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.69 µg/mL

Target

Target Organism D. bacillus

Source & Reference

Database Source dbAMP

Other

Evidence Text

2 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa AT

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75-37.5 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP

Other

Evidence Text

a (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and f

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP

Other

Evidence Text

738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 u

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 ug/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In vitro Toxicity : human RBC: 65.59% at 100 ug/m

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism C. glabrata

Source & Reference

Database Source dbAMP

Other

Evidence Text

inosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In vitro Toxicity : human RBC: 65.59% at 100 ug/ml. UPdated 5/2023

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus aureus ATCC25923 or MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

st Gram+ S. aureus ATCC25923 or MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MRSA (MIC 18.75 ug/mL), S. epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5 ug/mL

Target

Target Organism Enterococcus faecalis IS 981

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

epidermidis (MIC 18.75 ug/mL), N. asteroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxyt

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 ug/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

eroids (MIC 9.38 ug/ml), B. cereus (MIC 9.38 ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi I

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/ml), E. faecalis IS 981 (MIC 37.5 ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/mL), E. faecium IS 1299 (MIC 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5 µg/mL

Target

Target Organism S. paratyphi IS 738

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

C 18.75 ug/mL), Gram- E. coli ATCC25922 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.69 µg/mL

Target

Target Organism D. bacillus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

2 (MIC 18.75 ug/ml), K. oxytoca (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa AT

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75-37.5 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

a (MIC 18.75 ug/ml) , S. paratyphi IS 738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and f

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

738 (MIC 37.5 ug/ml), D. bacillus (MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 u

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 4.69 ug/ml), K. pneumoniae (MIC 18.75-37.5 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 ug/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

maltophilia (MIC 18.75 ug/ml), P. aeruginosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In vitro Toxicity : human RBC: 65.59% at 100 ug/m

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism C. glabrata

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

inosa ATCC 27853 (MIC 9.38-18.75 ug/ml), and fungi C. albicans (MIC 9.38-18.75 ug/mL) and C. glabrata (MIC 9.38-18.75 ug/ml). In vitro Toxicity : human RBC: 65.59% at 100 ug/ml. UPdated 5/2023

Evidence 31 Activity

Activity

Activity Endpoint 65.59% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

65.59% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 32 Activity

Activity

Activity Endpoint 8.74% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

8.74% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Target Cell Human hepatocyte cells HL-7702 (L02)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 33 Activity

Activity

Activity Endpoint 12.95% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

12.95% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Target Cell Murine peritoneal macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018

Evidence 34 Activity

Activity

Activity Endpoint 22.45% Degranulation

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

22.45% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018