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Peptide record

TPDB11109

Antibacterial Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11109
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 29-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFCIPIRCPGHTRQIGTCFGPRVKSCRKW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C145H231N47O34S4
ANDELMY
RCG
3304.96
10.57
7
0
7
+6
1.85
-0.300
50.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5750
1.74
8
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
1
Q
4
G
1
H
3
I
0
L
2
K
0
M
2
F
3
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 4 H: 1 I: 3 L: 0 K: 2 M: 0 F: 2 P: 3 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
29 reviewed residue count
C145H231N47O34S4 sequence-only estimate (linear, free termini)
3304.96 sequence-only estimate (linear, free termini)
10.57 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.85 sequence-only estimate (linear, free termini)
-0.300 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
<10% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Artificial beta-defensin based on a minimal defensin template. | Biochem J | 2009
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Artificial beta-defensin based on a minimal defensin template. | Biochem J | 2009
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis