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Peptide record

TPDB11106

Antibacterial Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11106
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 29-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RGLRRLGKKIAHGVKKYGPTVLRIIRIAG
Physicochemical Analysis
C146H260N50O32
NDCEQMFSW
RG
3227.99
12.59
10
0
12
+9
5.55
-0.190
121.03
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
46.16
2
Residue Composition
number
2
A
5
R
0
N
0
D
0
C
0
E
0
Q
5
G
1
H
4
I
3
L
4
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 1 I: 4 L: 3 K: 4 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
29
C146H260N50O32
3227.99
12.59
+9
5.55
-0.190
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
60.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 60.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
3.18 µM
Cytotoxic
50% Cell death | 3.18 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011