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Peptide record

TPDB11105

Antibacterial Anticancer Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11105
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
IKLSPETKKNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
C141H258N38O35S1
RDCQHFWY
K
3077.89
10.99
8
1
14
+7
7.79
0.155
124.48
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
3
I
3
L
8
K
1
M
0
F
1
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 8 M: 1 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
29
C141H258N38O35S1
3077.89
10.99
+7
7.79
0.155
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
174±12 µM
Hemolytic Cytotoxic
50% Hemolysis | 174±12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-tumor activities of the host-defense peptide hymenochirin-1B. | Regul Pept | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.24172540] LC₅₀ = 174 ± 12 µM against freshly prepared human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2013 Dec 50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15 14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.