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Peptide record

TPDB11095

Antibacterial Anticancer Antidiabetic Antifungal Hemolysis Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB11095
Antibacterial Anticancer Antidiabetic Antifungal Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
IKIPSFFRNILKKVGKEAVSLIAGALKQS
Physicochemical Analysis
C147H251N39O37
DCHMTWY
K
3156.85
11.10
6
1
14
+5
4.09
0.328
124.48
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
3
A
1
R
1
N
0
D
0
C
1
E
1
Q
2
G
0
H
4
I
3
L
5
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 0 I: 4 L: 3 K: 5 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
29
C147H251N39O37
3156.85
11.10
+5
4.09
0.328
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aer
Evidence 2 Activity

Activity

MIC
Antibacterial
1.25-2.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-10 uM), S. maltophilia (5
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

moniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-10 uM), S. maltophilia (5-10 uM), E. coli (MIC 10 uM), and C. albicans (80 uM). The peptide is also activ eagainst select cancer cell lines (A5
Evidence 5 Activity

Activity

MIC
Antifungal
5-10 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aer
Evidence 6 Activity

Activity

MIC
Antifungal
1.25-2.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5-10 uM), S. epidermidis (MIC 1.25-2.5 uM), E. faecalis (MIC 10 uM), K. pneumoniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-10 uM), S. maltophilia (5
Evidence 8 Activity

Activity

MIC
Antifungal
10 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

moniae (20 uM), P. aeruginosa (20 uM), A. baumannnii (5-10 uM), S. maltophilia (5-10 uM), E. coli (MIC 10 uM), and C. albicans (80 uM). The peptide is also activ eagainst select cancer cell lines (A5
Evidence 9 Activity

Activity

LC50
Hemolysis
403 µM
Human red blood cells (RBC): LC50>403 µM

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Regul Pept. 2014 Nov 194-195:69-76.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Cell death
Toxicity
5.6±0.9 µM
Cytotoxic
50% Cell death | 5.6±0.9 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa. | ACS Appl Mater Interfaces | 2014
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
28±2 µM
Hemolytic Cytotoxic
50% Hemolysis | 28±2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa. | ACS Appl Mater Interfaces | 2014
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
30±5 µM
Hemolytic Cytotoxic
50% Hemolysis | 30±5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities. | J Nat Prod | 2015
Evidence 13 Activity

Activity

LC50
Toxicity
403 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (RBC): LC50>403 µM | Cytotoxicity: HUVEC: LC50=5.6±0.9 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2014 Nov 194-195:69-76.
Evidence 14 Hemolysis

Activity

403 µM
LC50
Human red blood cells (RBC): LC50>403 µM
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Regul Pept. 2014 Nov 194-195:69-76.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.