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Peptide record

TPDB11093

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

29 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11093

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2

Sequence_Type

standard

Has_Modification No

Description A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GFMDTAKNVAKNVAVTLLDNLKCKITKAC

FASTA

>TPDB11093|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=29
GFMDTAKNVAKNVAVTLLDNLKCKITKAC

Formula C135H233N37O40S3

Absent Amino Acids REQHPSWY

Common Amino Acids K

Mass 3110.74

PI 9.65

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +3

Boman Index 4.80

Hydrophobicity 0.203

Aliphatic Index 97.59

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 4.02

Polar Residues 8

number

Amino Acid Distribution

A: 4 R: 0 N: 3 D: 2 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 5 M: 1 F: 1 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 3

Length

Formula

C135H233N37O40S3

Mass

3110.74

9.65

Net Charge

Boman Index

4.80

Hydrophobicity

0.203

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64-128 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 64-128 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022

Evidence 11 Hemolysis

Source & Reference

source HemoPI

Database Source NA